{"id":"W1966888621","doi":"10.1002/art.37750","title":"Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model","year":2012,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institutes of Health","keywords":"Cartilage; Aggrecan; Chondrocyte; In vivo; Matrix metalloproteinase; Apoptosis; Endocrinology; Type II collagen; Internal medicine; Sirtuin 1; Cartilage oligomeric matrix protein; Chemistry; Biology; Osteoarthritis; Molecular biology; Pathology; Medicine; Downregulation and upregulation; Anatomy; Biochemistry; Articular cartilage; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008469797,0.0002874127,0.0008095345,0.0003753168,0.00007832479,0.00002242938,0.0001125688,0.0002122034,0.0002644075],"category_scores_gemma":[0.0003286726,0.0002625448,0.0001449355,0.0003161176,0.0001096156,0.0004421487,0.00005284931,0.0002949721,0.00002525499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764291,"about_ca_system_score_gemma":0.0001035072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004103388,"about_ca_topic_score_gemma":0.0006329696,"domain_scores_codex":[0.9977315,0.00008217595,0.0006279914,0.0003526165,0.0004038987,0.0008017873],"domain_scores_gemma":[0.998816,0.0002071317,0.0001313009,0.000489512,0.00005915284,0.0002968597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001506485,0.003891756,0.03744825,0.001418039,0.0001869696,0.0001693215,0.04169592,0.0004508114,0.4562345,0.003131525,0.03469699,0.4191694],"study_design_scores_gemma":[0.09426811,0.003428695,0.04115359,0.01895007,0.0002958445,0.0007011108,0.005758374,0.2411822,0.5779856,0.005802753,0.007067865,0.003405732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875059,0.006779729,0.001577742,0.001891014,0.0002115712,0.001200821,0.00009829683,0.00006915723,0.0006658199],"genre_scores_gemma":[0.9900652,0.004163512,0.003275509,0.001063788,0.00008125192,0.0003415514,0.00001518416,0.00006069287,0.0009332662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4157637,"threshold_uncertainty_score":0.9999827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711615973392965,"score_gpt":0.2862501597021282,"score_spread":0.2591339999681986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}