{"id":"W1966888621","doi":"10.1002/art.37750","title":"Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model","year":2012,"lang":"en","type":"article","venue":"Arthritis & Rheumatism","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institutes of Health","keywords":"Cartilage; Aggrecan; Chondrocyte; In vivo; Matrix metalloproteinase; Apoptosis; Endocrinology; Type II collagen; Internal medicine; Sirtuin 1; Cartilage oligomeric matrix protein; Chemistry; Biology; Osteoarthritis; Molecular biology; Pathology; Medicine; Downregulation and upregulation; Anatomy; Biochemistry; Articular cartilage; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004833554,0.0009668925,0.0005501563,0.001108882,0.0003239423,0.0006280218,0.0005679723,0.0008551059,0.002774609],"category_scores_gemma":[0.0002885586,0.0004325436,0.000750521,0.0004220601,0.0007442519,0.0005467584,0.0004024148,0.001294944,0.00105283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000464782,"about_ca_system_score_gemma":0.0003608794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005581843,"about_ca_topic_score_gemma":0.0008124359,"domain_scores_codex":[0.9995412,0.00005015062,0.00005238376,0.0001346955,0.0001480025,0.00007361934],"domain_scores_gemma":[0.999212,0.00004332667,0.0004636839,0.0000778282,0.00006367327,0.0001393823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003344417,0.00007540997,0.0008698776,0.00006554775,0.0000215317,0.0001694502,0.00001829502,0.00005433628,0.9969128,0.00009100985,0.00009280026,0.001294591],"study_design_scores_gemma":[0.0002059014,0.002369089,0.02833176,0.00006600012,0.0001831898,0.003923226,0.0001350255,0.001506748,0.955863,0.0003000263,0.007087545,0.00002839615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761809,0.005820628,0.01320203,0.0005873569,0.0001228107,0.0001083433,0.001549991,0.000598854,0.001829163],"genre_scores_gemma":[0.9815159,0.003113944,0.007124017,0.0002334079,0.00005276758,0.0001970663,0.001612173,0.000138591,0.006012103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002774609,"threshold_uncertainty_score":0.009281933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711615973392965,"score_gpt":0.2862501597021282,"score_spread":0.2591339999681986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}