{"id":"W1966905733","doi":"10.1038/cgt.2009.83","title":"CUG2, a novel oncogene confers reoviral replication through Ras and p38 signaling pathway","year":2010,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Oncolytic virus; MAPK/ERK pathway; Oncogene; Transfection; Biology; Cancer research; Apoptosis; Cell biology; p38 mitogen-activated protein kinases; Cancer cell; Kinase; Molecular biology; Cell cycle; Cell culture; Cancer; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003976985,0.0002294383,0.0001903438,0.00004004887,0.0001590403,0.00004886728,0.0002928826,0.000210935,0.0001424563],"category_scores_gemma":[0.000026996,0.0002151385,0.00008358173,0.0001274633,0.0001945451,0.000009856631,0.00006199293,0.0002231963,0.000007342539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002707625,"about_ca_system_score_gemma":0.0003455563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001083885,"about_ca_topic_score_gemma":0.000234789,"domain_scores_codex":[0.9984527,0.00006051814,0.0002244301,0.0006917545,0.0002018813,0.0003687223],"domain_scores_gemma":[0.9987099,0.00001509757,0.0001043208,0.0008805995,0.0001688897,0.0001211468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001406763,0.0000587808,0.0004280818,0.000006076072,0.00009745925,0.000001117116,0.0001755403,0.00004329443,0.9546058,0.00005249953,0.0002411923,0.04288337],"study_design_scores_gemma":[0.001737362,0.0009982263,0.0001968578,0.000006032131,0.000006351551,0.00001166824,0.00003064367,0.0000467138,0.937287,0.0001286773,0.05929076,0.000259679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991051,0.006306915,0.001049799,0.000558168,0.0002271662,0.0004249911,0.00006597958,0.00002990868,0.0002860699],"genre_scores_gemma":[0.9901863,0.005145032,0.001267344,0.001674774,0.0008522914,0.0002010974,0.0001144045,0.00006812676,0.0004906397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05904956,"threshold_uncertainty_score":0.8773092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04073859269605616,"score_gpt":0.3403672380068577,"score_spread":0.2996286453108015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}