{"id":"W1966908666","doi":"10.1016/j.bone.2007.08.044","title":"Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway","year":2007,"lang":"en","type":"article","venue":"Bone","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alethia Biotherapeutics (Canada); McGill University; Western University","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Osteoclast; NFAT; Multinucleate; Extracellular; Cytosol; Endocrinology; Internal medicine; Bone resorption; Acidosis; Biology; Cell biology; Chemistry; Receptor; Biochemistry; Calcineurin; Medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008312374,0.0002068034,0.0001687939,0.00004524227,0.0001626829,0.00005401894,0.0002621499,0.0002239177,0.0001346409],"category_scores_gemma":[0.00008420371,0.0001972227,0.00008926279,0.0001114596,0.0000957326,0.00002588785,0.0001153244,0.0001779422,0.0001142062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002768641,"about_ca_system_score_gemma":0.0001118673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009342916,"about_ca_topic_score_gemma":0.0004037115,"domain_scores_codex":[0.9980257,0.0001215832,0.0003261847,0.0005720105,0.0004558775,0.0004986182],"domain_scores_gemma":[0.9989765,0.00001484319,0.0001127088,0.0006031247,0.0001211603,0.0001717231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002163312,0.0002560561,0.0002253227,0.00002147598,0.00002236037,0.00008781897,0.00006407276,0.000003928568,0.9894882,0.0006514663,0.00004911363,0.008913785],"study_design_scores_gemma":[0.0005288902,0.0003636277,0.0005193962,0.00001493854,0.000007144967,0.00000868674,0.0004525156,0.00001264876,0.9661375,0.00009164673,0.03161299,0.0002500705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687223,0.001787303,0.02593127,0.0001125699,0.0001227048,0.0004631245,0.00003537534,0.00002910906,0.002796266],"genre_scores_gemma":[0.991299,0.000111619,0.0009365099,0.00003151524,0.0005380143,0.00004965101,0.0002826788,0.00003799592,0.006713056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03156388,"threshold_uncertainty_score":0.804251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0264985550910757,"score_gpt":0.3030433580134378,"score_spread":0.2765448029223621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}