{"id":"W1966914649","doi":"10.1093/nar/gkq885","title":"The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element","year":2010,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research; Lomonosov Moscow State University","keywords":"Internal ribosome entry site; Luciferase; Biology; Translation (biology); Primer binding site; Untranslated region; Molecular biology; Negative regulatory element; Reporter gene; Cell biology; Five prime untranslated region; Transfection; Messenger RNA; RNA; Gene; Regulation of gene expression; Gene expression; Genetics; Regulatory sequence; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002723921,0.0003420708,0.000276493,0.000192218,0.0001805573,0.000425697,0.0002252367,0.0003286629,0.0009164395],"category_scores_gemma":[0.0002614198,0.0002103322,0.0002578965,0.00009554466,0.0004053745,0.0002481972,0.000211678,0.0005126387,0.0002868093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003357193,"about_ca_system_score_gemma":0.0001651309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001478809,"about_ca_topic_score_gemma":0.0001356876,"domain_scores_codex":[0.9997593,0.00004869082,0.00002074739,0.00007316437,0.0000578769,0.00004025448],"domain_scores_gemma":[0.9998005,0.00004368171,0.0000728918,0.00002825895,0.00002964731,0.00002491112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005889132,0.00001149795,0.0001999434,0.00001648648,0.000001929641,0.00002051315,0.00000789384,0.00002376309,0.9989581,0.00008822299,0.0000101366,0.0006026231],"study_design_scores_gemma":[0.00001386786,0.0001309806,0.006054,0.00001040126,0.000008093906,0.0002663552,0.00002259939,0.0005515011,0.9917039,0.00009571508,0.001137262,0.000005506316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993329,0.002020106,0.003298221,0.00009943999,0.00003365254,0.00002565269,0.0001778986,0.00005909722,0.0009569022],"genre_scores_gemma":[0.9939982,0.0009034337,0.003828036,0.00004702206,0.00001408926,0.00002866123,0.0002908285,0.00001033511,0.0008794655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009164395,"threshold_uncertainty_score":0.003065825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514888193663614,"score_gpt":0.3062836311953084,"score_spread":0.2911347492586722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}