{"id":"W1966916056","doi":"10.1016/j.molbrainres.2005.05.025","title":"Cholesterol biosynthesis and the pro-apoptotic effects of the p75 nerve growth factor receptor in PC12 pheochromocytoma cells","year":2005,"lang":"en","type":"article","venue":"Molecular Brain Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Biology; Low-affinity nerve growth factor receptor; Downregulation and upregulation; Apoptosis; Nerve growth factor; Receptor; Programmed cell death; HMG-CoA reductase; Reductase; Cell biology; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377005,0.0002303815,0.0003396881,0.0004377901,0.000471492,0.0004506937,0.0002215306,0.0003005384,0.000846598],"category_scores_gemma":[0.0002035187,0.0001676142,0.0003249677,0.0003857434,0.0003110153,0.0004132594,0.0002158755,0.0005686778,0.0003185469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001147259,"about_ca_system_score_gemma":0.0005859617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01528246,"about_ca_topic_score_gemma":0.0154697,"domain_scores_codex":[0.999759,0.00003320146,0.00002273889,0.00002814447,0.00007271368,0.00008411767],"domain_scores_gemma":[0.9998449,0.00004970261,0.00002030318,0.00002267772,0.00002828056,0.00003415551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007512716,0.00004368457,0.0003303842,0.00003624647,0.000007453875,0.0003088622,0.00005854507,0.0000943225,0.9967034,0.0002387822,0.00005324726,0.001373619],"study_design_scores_gemma":[0.00003187247,0.0002222094,0.005698608,0.000003185107,0.00001329659,0.0002689919,0.0001042593,0.0005906317,0.9914911,0.00007899745,0.001488294,0.000008485974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958602,0.001741551,0.0005410089,0.0001380625,0.00002043967,0.000009093261,0.0002895119,0.00003046019,0.001369718],"genre_scores_gemma":[0.9959574,0.000826047,0.00046807,0.00002372687,0.000005811204,0.00001064594,0.0003040673,0.00000763395,0.002396581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01528246,"threshold_uncertainty_score":0.03038698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01342757244531658,"score_gpt":0.3001132212426467,"score_spread":0.2866856487973301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}