{"id":"W1966934571","doi":"10.1152/ajpregu.00293.2004","title":"The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism","year":2004,"lang":"en","type":"article","venue":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":358,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Douglas College","funders":"","keywords":"Saline; Tumor necrosis factor alpha; Cytokine; Endocrinology; Interleukin; Internal medicine; Chemistry; Receptor antagonist; In vivo; Interleukin 6; Inflammation; Pharmacology; Antagonist; Medicine; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702577,0.0008723335,0.0004172036,0.0004717579,0.0001725289,0.0002791476,0.0002330336,0.0003390452,0.0009935086],"category_scores_gemma":[0.0001929698,0.0002551001,0.0003792672,0.0002154938,0.0006008779,0.000273281,0.0001872567,0.0008757034,0.0002718385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003899429,"about_ca_system_score_gemma":0.0003585935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005124479,"about_ca_topic_score_gemma":0.0008155152,"domain_scores_codex":[0.9997928,0.00003644817,0.00001318882,0.00005052911,0.000041605,0.00006551924],"domain_scores_gemma":[0.999633,0.00003569838,0.00017146,0.00003972883,0.00002182962,0.00009835288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002407765,0.0002380602,0.0004049988,0.00004687745,0.00001105342,0.00007556649,0.00002549609,0.0001101086,0.9945807,0.00007253227,0.00004615834,0.001980693],"study_design_scores_gemma":[0.0001858784,0.01432808,0.007709369,0.00001547126,0.00005732094,0.0003225584,0.0000605532,0.001201812,0.9751468,0.00009195518,0.0008640894,0.0000160898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967219,0.00084719,0.00159524,0.00005472471,0.00004565627,0.00003215314,0.0001573609,0.0001072066,0.0004385954],"genre_scores_gemma":[0.9948773,0.001003714,0.002377911,0.00004716051,0.00003397424,0.0001016613,0.0003222649,0.00002008855,0.001216056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009935086,"threshold_uncertainty_score":0.003323674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708141211347244,"score_gpt":0.2684593863103504,"score_spread":0.251377974196878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}