{"id":"W1966975812","doi":"10.1016/j.nmd.2012.06.154","title":"T.P.8 Induction of SMN protein by combination of STAT5 and p38 kinase activating, clinic ready compounds for the treatment of SMA","year":2012,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"","keywords":"SMN1; SMA*; Spinal muscular atrophy; STAT5; Motor neuron; Downregulation and upregulation; Biology; Protein kinase A; Cancer research; Cell biology; Signal transduction; Kinase; Gene; Neuroscience; Genetics; Spinal cord","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181298,0.0003532634,0.0002363811,0.0002705823,0.0001839406,0.0001471397,0.0001973825,0.0002569834,0.002658822],"category_scores_gemma":[0.00006726477,0.00009789531,0.0003129495,0.0001112473,0.0001435243,0.0001490794,0.0001278452,0.0005938505,0.0003282233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349071,"about_ca_system_score_gemma":0.0002581858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004047629,"about_ca_topic_score_gemma":0.001383263,"domain_scores_codex":[0.9999567,0.00000781564,0.000003546499,0.000006159646,0.000007978627,0.00001772509],"domain_scores_gemma":[0.9999844,0.00000254596,0.000003992855,0.000001591021,0.000001533302,0.000005949814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004237544,0.001205105,0.0003757712,0.0003037706,0.00006134993,0.0005088623,0.00003631807,0.0007450481,0.9416896,0.0007906467,0.001374704,0.04867134],"study_design_scores_gemma":[0.001623684,0.02238298,0.004401286,0.00003798453,0.0002085735,0.001532142,0.00005443042,0.002595905,0.9544724,0.0004104192,0.01226157,0.0000186198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983315,0.007809821,0.002452609,0.000428456,0.0001877986,0.0001021174,0.0002339062,0.0001513123,0.005319013],"genre_scores_gemma":[0.991985,0.002895977,0.001423089,0.00007450419,0.0000478604,0.00006163816,0.0002062545,0.000008378581,0.003297243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002658822,"threshold_uncertainty_score":0.008894622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03731202970575681,"score_gpt":0.328056827744967,"score_spread":0.2907447980392102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}