{"id":"W1966996749","doi":"10.1016/j.clim.2009.03.359","title":"F.106. Granzyme B Mediates T Cell-induced Neurotoxicity through Cytoskeletal Disruption in Human Cortical Neurons","year":2009,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytoskeleton; Immunostaining; Biology; Microtubule; Neurofilament; Tubulin; Cell biology; Microtubule-associated protein; Neuroscience; Neurofibrillary tangle; Neuron; Pathology; Immunohistochemistry; Cell; Immunology; Medicine; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00032739,0.000229328,0.0004088173,0.00005402834,0.0001221537,0.00001492423,0.0002891936,0.0006938135,0.0001234604],"category_scores_gemma":[0.0006882159,0.0002198609,0.0002296127,0.0001330244,0.0003016284,0.000009052301,0.0001158337,0.0007496282,0.00009665941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000011137,"about_ca_system_score_gemma":0.0000522562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001753263,"about_ca_topic_score_gemma":0.00004845819,"domain_scores_codex":[0.9972116,0.0007942232,0.0007865948,0.0006729129,0.00008960455,0.0004450156],"domain_scores_gemma":[0.9990436,0.0001275906,0.0001522613,0.0005289858,0.00005315036,0.00009437012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003156613,0.0005594937,0.004964414,0.000002679677,0.00001602477,0.00004222788,0.00002559435,0.000004634293,0.9914343,0.0008613107,0.0005736743,0.001199968],"study_design_scores_gemma":[0.008671855,0.01701952,0.5416858,0.00001926687,0.0001034051,0.0002089778,0.0001013618,0.00009965952,0.4003988,0.004071868,0.026569,0.00105045],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944487,0.0001727385,0.0009292135,0.0008155095,0.00141868,0.0003086566,0.000005526863,0.00004053227,0.001860412],"genre_scores_gemma":[0.9961418,0.0002990621,0.0001875233,0.002366094,0.0005577889,0.00002258492,0.0001521511,0.00001933096,0.0002536801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5910355,"threshold_uncertainty_score":0.8965667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04100440013282154,"score_gpt":0.3520509198975942,"score_spread":0.3110465197647727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}