{"id":"W1967009210","doi":"10.1371/journal.pone.0009209","title":"Therapeutic Efficacy of Human Hepatocyte Transplantation in a SCID/uPA Mouse Model with Inducible Liver Disease","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"KMT Hepatech (Canada); Alberta Hospital Edmonton; University of Alberta Hospital; University of Alberta","funders":"Canadian Institutes of Health Research; Fondation pour la Recherche Médicale","keywords":"Humanized mouse; Transplantation; Genetically modified mouse; Ganciclovir; Liver transplantation; Transgene; Parenchyma; Hepatocyte; Biology; Cancer research; Thymidine kinase; Severe combined immunodeficiency; In vivo; Liver disease; Pathology; Medicine; Immunology; Immune system; Herpes simplex virus; In vitro; Virus; Internal medicine; Human cytomegalovirus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004888438,0.0009582868,0.000613267,0.0008411374,0.0002745149,0.0005056864,0.0003055548,0.0006516736,0.001713045],"category_scores_gemma":[0.0001582199,0.0001553094,0.0004924259,0.0003588069,0.0005912692,0.0003665253,0.0002794309,0.0009914293,0.0004529876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096502,"about_ca_system_score_gemma":0.0003243663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002568027,"about_ca_topic_score_gemma":0.0002838558,"domain_scores_codex":[0.9997165,0.00005592774,0.00003485061,0.00005872244,0.00007791904,0.00005616667],"domain_scores_gemma":[0.9997585,0.00002948085,0.00007640656,0.00003856029,0.00001821696,0.00007881709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00115949,0.000739367,0.0002423864,0.0001362135,0.00002092379,0.0002389947,0.00003098193,0.0002328907,0.9933374,0.0001608211,0.0001179146,0.003582568],"study_design_scores_gemma":[0.0001715404,0.007153133,0.002287604,0.00002114057,0.00008533017,0.0008352729,0.00003460854,0.001004149,0.9858719,0.00007669216,0.002446644,0.00001202526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898639,0.003048136,0.003547405,0.0001846757,0.0001622221,0.0001970766,0.0005237228,0.00027551,0.002197247],"genre_scores_gemma":[0.9911677,0.001700691,0.002705536,0.00008514462,0.00003971589,0.0001799369,0.0007683932,0.00003523509,0.00331769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001713045,"threshold_uncertainty_score":0.005730689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05178169318786812,"score_gpt":0.2885644490902313,"score_spread":0.2367827559023632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}