{"id":"W1967114867","doi":"10.1016/j.stem.2015.01.017","title":"CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells","year":2015,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":338,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Haematopoiesis; Cell biology; Stem cell; Cyclin-dependent kinase 6; Cell division; Hematopoietic stem cell; Cell cycle; Immunology; Cell; Kinase; Genetics; Cyclin-dependent kinase 2; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008261786,0.0004911424,0.0008265218,0.0004610775,0.00009325432,0.00006141747,0.0003519241,0.000337021,0.0002254966],"category_scores_gemma":[0.000002536407,0.0004788283,0.0001710331,0.0007877928,0.000137883,0.0001777742,0.0000759949,0.0004382375,0.001134327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002674318,"about_ca_system_score_gemma":0.0002361791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008253618,"about_ca_topic_score_gemma":0.00002043256,"domain_scores_codex":[0.996304,0.0002024404,0.001030722,0.0008092743,0.0008458798,0.0008076223],"domain_scores_gemma":[0.9978259,0.0001403204,0.0002739635,0.0009472034,0.0001789832,0.0006336073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003225999,0.001334311,0.01421502,0.006451919,0.00004558372,0.001708966,0.01860396,0.0003809404,0.9473823,0.0004600537,0.008139526,0.0009548342],"study_design_scores_gemma":[0.005351557,0.0003596284,0.001321587,0.0007615125,0.0001344811,0.0001457746,0.003895678,0.000301098,0.9840081,0.000167262,0.002953393,0.000599982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9283968,0.0008782834,0.0008507838,0.0001577021,0.0005296115,0.001236114,0.00001682745,0.000207046,0.06772685],"genre_scores_gemma":[0.9735403,0.00007458931,0.0006173049,0.0001798973,0.0001080431,0.00005066607,0.00002256436,0.0001073548,0.02529925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04514355,"threshold_uncertainty_score":0.9997663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05321765601204948,"score_gpt":0.2756034933816989,"score_spread":0.2223858373696495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}