{"id":"W1967114867","doi":"10.1016/j.stem.2015.01.017","title":"CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells","year":2015,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":338,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Biology; Haematopoiesis; Cell biology; Stem cell; Cyclin-dependent kinase 6; Cell division; Hematopoietic stem cell; Cell cycle; Immunology; Cell; Kinase; Genetics; Cyclin-dependent kinase 2; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008877285,0.0001063411,0.000122152,0.0001846308,0.0001414618,0.0004099704,0.00008977362,0.00007667254,0.0009763588],"category_scores_gemma":[0.000229658,0.00008108485,0.000112659,0.000133478,0.0001502509,0.0001507583,0.0001096202,0.0001511938,0.000223049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003550302,"about_ca_system_score_gemma":0.0001843986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001271256,"about_ca_topic_score_gemma":0.001706379,"domain_scores_codex":[0.9999536,0.0000067981,0.000003935017,0.00001238008,0.00001168926,0.00001151804],"domain_scores_gemma":[0.9999484,0.00001243042,0.00001651326,0.000003993245,0.000006719813,0.00001188928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001060149,0.00006666958,0.01971314,0.0000774117,0.00002262554,0.00008384557,0.00008609043,0.004517872,0.9589989,0.001411979,0.0001716697,0.01378961],"study_design_scores_gemma":[0.00004708132,0.0002346884,0.05839165,0.000008436788,0.00003295739,0.0002155893,0.00009392556,0.014725,0.9219994,0.0009467817,0.003290666,0.00001378554],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967799,0.0009399062,0.001188427,0.00002910742,0.000003112233,0.000004647303,0.0002226779,0.00002104398,0.0008113285],"genre_scores_gemma":[0.9990035,0.0002803346,0.0002934417,0.000005776218,0.000001384561,0.000002435101,0.0001245109,0.000006129806,0.0002824729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001271256,"threshold_uncertainty_score":0.003266215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05321765601204948,"score_gpt":0.2756034933816989,"score_spread":0.2223858373696495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}