{"id":"W1967122702","doi":"10.1517/17425255.1.4.655","title":"Drug-induced mitochondrial toxicity","year":2005,"lang":"en","type":"review","venue":"Expert Opinion on Drug Metabolism & Toxicology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Mitochondrion; Mitochondrial permeability transition pore; Oxidative phosphorylation; Programmed cell death; Mitochondrial DNA; Mitochondrial toxicity; Oxidative stress; Cell biology; Biology; Apoptosis; Mitochondrial respiratory chain; Cytochrome c; Respiratory chain; Biochemistry; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003194898,0.00114647,0.00148557,0.001296778,0.0003691532,0.0009062855,0.000850018,0.001538622,0.005872194],"category_scores_gemma":[0.0002826435,0.0001709225,0.0005296102,0.001069482,0.000502347,0.0007340627,0.0007676767,0.001036245,0.00530009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009716206,"about_ca_system_score_gemma":0.0004882966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006530521,"about_ca_topic_score_gemma":0.00116872,"domain_scores_codex":[0.9997721,0.00003980437,0.00001988897,0.00004420059,0.00009985084,0.00002411397],"domain_scores_gemma":[0.9998524,0.00003883096,0.00003729795,0.0000087581,0.00004439442,0.0000183171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008964037,0.0001050778,0.0003289231,0.01303854,0.0001234759,0.002864925,0.00009089739,0.0005883453,0.02588359,0.007783249,0.07503494,0.8740684],"study_design_scores_gemma":[0.00003363137,0.0001673424,0.001136124,0.001379798,0.00008109402,0.01221474,0.00005591649,0.000174348,0.01118577,0.003483718,0.9700614,0.00002597592],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009754512,0.9867445,0.001038436,0.000688054,0.0005499562,0.00002929542,0.00009052051,0.00008026337,0.009803464],"genre_scores_gemma":[0.007520427,0.9825798,0.0007106869,0.0009817128,0.000297836,0.00003463167,0.0001513763,0.00001100745,0.007712544],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005872194,"threshold_uncertainty_score":0.01964444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03520963181503899,"score_gpt":0.3475526792584428,"score_spread":0.3123430474434038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}