{"id":"W1967214137","doi":"10.1172/jci40259","title":"Engaging the lysosomal compartment to combat B cell malignancies","year":2009,"lang":"en","type":"letter","venue":"Journal of Clinical Investigation","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Response Biomedical (Canada)","funders":"Medical Research Council; Novo Nordisk; H. Lundbeck A/S; Lundbeckfonden; Sundhed og Sygdom, Det Frie Forskningsråd; Danmarks Grundforskningsfond; National Research Foundation; European Commission; Novo Nordisk Fonden; Kræftens Bekæmpelse","keywords":"CD20; Rituximab; B cell; Programmed cell death; Lymphoma; Medicine; Immunology; Lysosome; Monoclonal antibody; Cancer research; Apoptosis; Antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004717046,0.0004389547,0.0005194148,0.0002655635,0.0007769875,0.0007784453,0.0004064396,0.009188614,0.002570599],"category_scores_gemma":[0.002853496,0.0002006446,0.0003675247,0.0001748437,0.0008115036,0.000990389,0.0003566016,0.005821847,0.00323976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001224771,"about_ca_system_score_gemma":0.0005278931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004037724,"about_ca_topic_score_gemma":0.0009541292,"domain_scores_codex":[0.9996036,0.0001634617,0.0000391572,0.00003494974,0.00009969919,0.00005904616],"domain_scores_gemma":[0.9994423,0.000286912,0.00004940383,0.00002867964,0.0001037111,0.00008902686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002956722,0.0002253138,0.002602008,0.0003344637,0.00003513732,0.02307712,0.000178488,0.0003190491,0.005550771,0.006417315,0.8629059,0.09805885],"study_design_scores_gemma":[0.0006496047,0.0005252609,0.002748658,0.0002513928,0.00004250612,0.06282413,0.0002570066,0.001785474,0.00361017,0.01303594,0.9142329,0.00003695208],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.01286849,0.02527282,0.001124388,0.9194705,0.01798459,0.00007362816,0.00006200354,0.0002117247,0.02293184],"genre_scores_gemma":[0.1447249,0.02628737,0.002623103,0.7009361,0.08507798,0.0001667601,0.00008517119,0.00004818482,0.04005042],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.009188614,"threshold_uncertainty_score":0.008886397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1314796178940679,"score_gpt":0.406458272408917,"score_spread":0.2749786545148492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}