{"id":"W1967230571","doi":"10.1038/onc.2009.191","title":"PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Beatson Institute for Cancer Research; Sidney Kimmel Center for Prostate and Urologic Cancers; Sidney Kimmel Comprehensive Cancer Center; University of Texas MD Anderson Cancer Center; University of Kent; Cancer Research UK","keywords":"Biology; Cancer research; Epidermal growth factor receptor; Ectopic expression; Downregulation and upregulation; Gene knockdown; Transcription factor; Apoptosis; Cell cycle; Head and neck squamous-cell carcinoma; EGFR inhibitors; Small hairpin RNA; Cell growth; Cell culture; Cancer; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773049,0.00008030062,0.0001239734,0.00004433798,0.00001623635,0.000004463293,0.00007818054,0.0001112273,0.000002445796],"category_scores_gemma":[0.00003763582,0.00006113202,0.00001716193,0.0001236387,0.00004477861,0.000004275689,0.00002718343,0.00006433509,8.387336e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002211365,"about_ca_system_score_gemma":0.0000715592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002551728,"about_ca_topic_score_gemma":0.0001226777,"domain_scores_codex":[0.9993892,0.0000532235,0.0001920023,0.0001688696,0.00009351657,0.0001032115],"domain_scores_gemma":[0.9997242,0.00000950735,0.00008110368,0.0001334503,0.00002957954,0.00002212343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006822695,0.0000510041,0.007566028,0.00003831456,0.000005681016,6.089557e-7,0.0003695831,0.00001709542,0.9851695,0.000008005572,0.00004986145,0.006656094],"study_design_scores_gemma":[0.0007912948,0.0004214193,0.0138659,0.00006081149,0.000007301898,0.000002492035,0.0004870192,0.00002394165,0.98384,0.00005836791,0.0003730344,0.00006839871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978109,0.001582322,0.000008458133,0.0001424855,0.00003548014,0.000129472,0.000004115245,0.000001335755,0.0002854594],"genre_scores_gemma":[0.9982336,0.001447269,0.0001234608,0.0001025373,0.00003203089,0.000008761336,0.0000363557,0.000004326236,0.00001167147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006587696,"threshold_uncertainty_score":0.2492892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414910921244412,"score_gpt":0.265533003603013,"score_spread":0.2513838943905689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}