{"id":"W1967230571","doi":"10.1038/onc.2009.191","title":"PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Beatson Institute for Cancer Research; Sidney Kimmel Center for Prostate and Urologic Cancers; Sidney Kimmel Comprehensive Cancer Center; University of Texas MD Anderson Cancer Center; University of Kent; Cancer Research UK","keywords":"Biology; Cancer research; Epidermal growth factor receptor; Ectopic expression; Downregulation and upregulation; Gene knockdown; Transcription factor; Apoptosis; Cell cycle; Head and neck squamous-cell carcinoma; EGFR inhibitors; Small hairpin RNA; Cell growth; Cell culture; Cancer; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000234916,0.0003043755,0.0002892839,0.000573257,0.0004595643,0.0005144202,0.0002786825,0.0002478647,0.001305324],"category_scores_gemma":[0.0001995458,0.00015681,0.0003479097,0.0002850357,0.0004252939,0.0003534654,0.0002748569,0.0004080515,0.0003411456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006243775,"about_ca_system_score_gemma":0.0005107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002693287,"about_ca_topic_score_gemma":0.001724148,"domain_scores_codex":[0.9998341,0.00002945885,0.00001810238,0.00001996514,0.00004152827,0.00005689633],"domain_scores_gemma":[0.9999255,0.00001245832,0.00001928588,0.0000166476,0.0000125365,0.00001357854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007405002,0.00004906104,0.0007799665,0.0001055857,0.00001840151,0.000782802,0.00007043868,0.0001572372,0.9899478,0.0009982063,0.0001008133,0.006249169],"study_design_scores_gemma":[0.00002592804,0.0001046955,0.006928003,0.000005620589,0.00002885509,0.001000083,0.00008769989,0.000380258,0.9878419,0.0001863145,0.003405846,0.000004925337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860449,0.007729555,0.002257181,0.0001841053,0.00002736753,0.0000294761,0.0002991826,0.0001186353,0.00330957],"genre_scores_gemma":[0.9955608,0.001412249,0.0004992327,0.00002291264,0.000005378901,0.00001292244,0.0001306724,0.000007534371,0.002348322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002693287,"threshold_uncertainty_score":0.005355239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414910921244412,"score_gpt":0.265533003603013,"score_spread":0.2513838943905689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}