{"id":"W1967274572","doi":"10.1002/ana.21340","title":"A nasal proteosome adjuvant activates microglia and prevents amyloid deposition","year":2008,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Smiths Detection (Canada); GlaxoSmithKline (Canada)","funders":"National Institute on Aging; National Institutes of Health; Alzheimer's Association","keywords":"Microglia; Medicine; Lymph node; Downregulation and upregulation; Amyloid (mycology); Pathology; Alzheimer's disease; Immunology; Internal medicine; Endocrinology; Inflammation; Chemistry; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001327085,0.0004257689,0.0003005865,0.0001367146,0.000106288,0.0001818322,0.0001435847,0.0003346262,0.0007754561],"category_scores_gemma":[0.0001259648,0.00009488512,0.000178858,0.00004237193,0.0001731379,0.0001775376,0.0001342902,0.0003687125,0.000324094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462437,"about_ca_system_score_gemma":0.000211806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002558498,"about_ca_topic_score_gemma":0.0004922178,"domain_scores_codex":[0.9999102,0.00001197343,0.000005183971,0.00001748878,0.00002277096,0.00003242408],"domain_scores_gemma":[0.9999114,0.000007750224,0.0000341583,0.000008626356,0.00001396319,0.00002408793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004174714,0.0001227823,0.0001062744,0.0000363683,0.000002961677,0.00003861394,0.000006438522,0.00002100976,0.9975829,0.00001435651,0.00002544744,0.001625418],"study_design_scores_gemma":[0.0002043669,0.007827906,0.004926186,0.00002959882,0.00004470098,0.0006940397,0.00003537869,0.0005952474,0.983352,0.00004671752,0.002237743,0.000006128495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972287,0.001070452,0.0009088354,0.00005665447,0.00003539427,0.00003346738,0.00006643468,0.00005749354,0.0005426079],"genre_scores_gemma":[0.9956012,0.001043932,0.001324582,0.00007469077,0.00002844729,0.00005098328,0.0001674294,0.00001457367,0.001694151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007754561,"threshold_uncertainty_score":0.002594173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06136203465981314,"score_gpt":0.3383529116607253,"score_spread":0.2769908770009121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}