{"id":"W1967280262","doi":"10.1099/vir.0.005447-0","title":"Reverse genetics-generated elastase-dependent swine influenza viruses are attenuated in pigs","year":2009,"lang":"en","type":"article","venue":"Journal of General Virology","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Mutant; Biology; Reverse genetics; Virology; Attenuated vaccine; Virus; Influenza A virus; Elastase; Arginine; Serial passage; Wild type; Molecular biology; Gene; Microbiology; Genetics; Virulence; Amino acid; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006369639,0.0005807694,0.0003396832,0.0003338897,0.0001470213,0.0002991844,0.0004731085,0.00071957,0.00100845],"category_scores_gemma":[0.0003642765,0.0003824621,0.0005241953,0.0001110769,0.0002929695,0.0002428188,0.0002129208,0.0009570563,0.0006983418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840159,"about_ca_system_score_gemma":0.0001666866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002827341,"about_ca_topic_score_gemma":0.0004283634,"domain_scores_codex":[0.9995234,0.0001676468,0.00005749108,0.00006490661,0.00009433074,0.00009211253],"domain_scores_gemma":[0.9996799,0.00009522269,0.0001004263,0.00005462435,0.00002894378,0.00004081467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009232204,0.0000598985,0.0002220765,0.0000230438,0.000007650887,0.00009601722,0.00001445237,0.00004065039,0.9985241,0.00008106538,0.00004952621,0.0007891713],"study_design_scores_gemma":[0.0001096888,0.003484457,0.006932839,0.00002870477,0.00006233997,0.001997197,0.00005117379,0.001403021,0.9807175,0.0001043668,0.005093895,0.0000148508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898748,0.0006239368,0.006802991,0.0001814584,0.0001202413,0.0001293035,0.0004168653,0.00009600207,0.001754313],"genre_scores_gemma":[0.9805674,0.0007751693,0.01193581,0.0002105153,0.00003843657,0.0001873768,0.001672703,0.0000795454,0.004532956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00100845,"threshold_uncertainty_score":0.003373623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08741928831905328,"score_gpt":0.3851101362126205,"score_spread":0.2976908478935672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}