{"id":"W1967291345","doi":"10.1038/ng849","title":"Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer","year":2002,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":1634,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hatch (Canada)","funders":"U.S. Public Health Service","keywords":"Biology; Cancer research; Genetics; Germline mutation; Compound heterozygosity; Mutation; Pathogenesis; Germline; Fumarase; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001960222,0.0005880982,0.0002796031,0.00127783,0.000535536,0.0002776508,0.0002640188,0.0007871636,0.006348432],"category_scores_gemma":[0.001131934,0.0001935048,0.0003272197,0.0005487007,0.0005045771,0.0001909216,0.0002970851,0.0004311549,0.000306345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002116071,"about_ca_system_score_gemma":0.0002750527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001902546,"about_ca_topic_score_gemma":0.002281704,"domain_scores_codex":[0.999778,0.0000546071,0.00001775324,0.00004832747,0.00005362102,0.00004772064],"domain_scores_gemma":[0.9995703,0.0002096259,0.0000893316,0.00002537634,0.00002347556,0.00008178328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002903302,0.0004389111,0.297393,0.0002141609,0.0003944848,0.2735378,0.0012079,0.0009488548,0.3691576,0.006265775,0.002550059,0.04498819],"study_design_scores_gemma":[0.0001930757,0.0006963293,0.4690756,0.00005211295,0.000445144,0.4853105,0.0006445031,0.002250437,0.03329946,0.002414387,0.005559306,0.00005911584],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905098,0.0008098637,0.001329714,0.0004269661,0.0000477186,0.00002279913,0.0001980263,0.00008407902,0.006571063],"genre_scores_gemma":[0.9983283,0.0001594671,0.0003699541,0.00004908544,0.00004265231,0.000003048362,0.00004022984,0.00001205904,0.0009952737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006348432,"threshold_uncertainty_score":0.02123761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141375353751785,"score_gpt":0.2803279826685731,"score_spread":0.2661904472933946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}