{"id":"W1967292512","doi":"10.1160/th11-09-0604","title":"Reduction of thrombus size in murine models of thrombosis following administration of recombinant α1-proteinase inhibitor mutant proteins","year":2012,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Blood Services","keywords":"Recombinant DNA; Thrombosis; Thrombus; Mutant; Proteinase inhibitor; Reduction (mathematics); Medicine; Pharmacology; Chemistry; Biochemistry; Internal medicine; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005748048,0.001020228,0.0006033432,0.0009069493,0.0002339176,0.0004878934,0.000538533,0.0008406967,0.00144461],"category_scores_gemma":[0.0002517625,0.0003806204,0.00056732,0.0003208707,0.0004553589,0.0003899676,0.0001995795,0.001810743,0.0005330169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005151812,"about_ca_system_score_gemma":0.0002682666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005168451,"about_ca_topic_score_gemma":0.0006613828,"domain_scores_codex":[0.9994504,0.0001361597,0.00006210167,0.0001081898,0.0001244299,0.0001187683],"domain_scores_gemma":[0.9994298,0.00007122508,0.0002451321,0.00005581453,0.00004401386,0.0001541124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009877312,0.0005778555,0.0001484778,0.000068327,0.00002325884,0.0001149603,0.00003969967,0.0001806594,0.996093,0.0001946216,0.0001290666,0.001442359],"study_design_scores_gemma":[0.0001869024,0.006269678,0.00152745,0.00001237711,0.00004571191,0.0004226648,0.0000202628,0.001529178,0.9882628,0.00006933603,0.001643827,0.000009803807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863883,0.002293735,0.007008361,0.0003362687,0.000140275,0.0003145155,0.001128135,0.0004712468,0.001919174],"genre_scores_gemma":[0.9804111,0.001964888,0.00927714,0.000178342,0.00008337955,0.0003891626,0.001625584,0.00008457523,0.005985937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144461,"threshold_uncertainty_score":0.004832685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07431781783352283,"score_gpt":0.3223767645947828,"score_spread":0.2480589467612599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}