{"id":"W1967320582","doi":"10.1128/jb.00525-10","title":"The ABC Transporter HrtAB Confers Resistance to Hemin Toxicity and Is Regulated in a Hemin-Dependent Manner by the ChrAS Two-Component System in<i>Corynebacterium diphtheriae</i>","year":2010,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Petroleum Technology Research Centre","keywords":"Hemin; Biology; Operon; Corynebacterium diphtheriae; Heme; Mutant; Gene; ATP-binding cassette transporter; Plasmid; Molecular biology; Microbiology; Biochemistry; Transporter; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009602885,0.0002552898,0.0002386625,0.000191222,0.0001052731,0.0002818102,0.0001481731,0.0002001693,0.0007382435],"category_scores_gemma":[0.0001724924,0.0001413333,0.0002287275,0.0001869488,0.0001663272,0.0001119353,0.0002354463,0.0003467557,0.0003785861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005751459,"about_ca_system_score_gemma":0.0002835726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003239121,"about_ca_topic_score_gemma":0.002656996,"domain_scores_codex":[0.9998275,0.00002170956,0.00001556032,0.00003567661,0.00005970891,0.00003977258],"domain_scores_gemma":[0.9998572,0.00002127321,0.00003885625,0.00002091471,0.00003315198,0.00002856566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001941694,0.000004609381,0.0002027551,0.000008661907,0.000001161143,0.000025506,0.000005532618,0.00001930549,0.9992827,0.00002131507,0.00001578673,0.0003932491],"study_design_scores_gemma":[0.00001522249,0.0001101891,0.03775872,0.00000656279,0.00001404498,0.0004676969,0.00005507432,0.002203369,0.9574653,0.00004513102,0.001850078,0.000008651258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956519,0.0005055941,0.002411362,0.0001082249,0.00001888041,0.00001541773,0.0004643687,0.00008222917,0.0007420318],"genre_scores_gemma":[0.9941607,0.000234923,0.002305823,0.00005577842,0.000005337268,0.00002015353,0.0008958818,0.00002507334,0.002296135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003239121,"threshold_uncertainty_score":0.00644052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003884385353130683,"score_gpt":0.2087494685254712,"score_spread":0.2048650831723405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}