{"id":"W1967320582","doi":"10.1128/jb.00525-10","title":"The ABC Transporter HrtAB Confers Resistance to Hemin Toxicity and Is Regulated in a Hemin-Dependent Manner by the ChrAS Two-Component System in<i>Corynebacterium diphtheriae</i>","year":2010,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Petroleum Technology Research Centre","keywords":"Hemin; Biology; Operon; Corynebacterium diphtheriae; Heme; Mutant; Gene; ATP-binding cassette transporter; Plasmid; Molecular biology; Microbiology; Biochemistry; Transporter; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007618863,0.0002390597,0.0004046276,0.00007156902,0.00009040277,0.00004966024,0.000505066,0.000403921,0.00001130336],"category_scores_gemma":[0.00003968571,0.0001479517,0.00009111589,0.000104077,0.0002898266,0.000005888594,0.0001100201,0.0004996185,0.000001464637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003732606,"about_ca_system_score_gemma":0.00007053857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000488687,"about_ca_topic_score_gemma":0.001284557,"domain_scores_codex":[0.9982769,0.0001317052,0.0007457329,0.0003341249,0.0001164033,0.0003951156],"domain_scores_gemma":[0.9989626,0.00003973539,0.0003506533,0.000428488,0.0001098104,0.0001086738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008975446,0.00005786613,0.001909986,0.000015102,0.00004573097,0.00002385143,0.0001376649,0.00000174224,0.9954574,0.00004721074,0.0005129104,0.000892989],"study_design_scores_gemma":[0.00223543,0.0005398752,0.04640912,0.00007656936,0.00002963912,0.0004750408,0.0003114561,0.000009179714,0.8111266,0.00004589824,0.1384258,0.000315387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941014,0.0005841893,0.00001737313,0.004164057,0.0007363432,0.0002623139,0.00004852323,0.000004053596,0.00008176779],"genre_scores_gemma":[0.9985222,0.000398879,0.0001022776,0.0005395927,0.0002025883,0.00001680858,0.00001091977,0.0000225923,0.0001841386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1843308,"threshold_uncertainty_score":0.6033294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003884385353130683,"score_gpt":0.2087494685254712,"score_spread":0.2048650831723405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}