{"id":"W1967362046","doi":"10.1038/modpathol.3800996","title":"WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer","year":2007,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Gary Bennett Family Fund; National Cancer Institute; Entertainment Industry Foundation","keywords":"Microsatellite instability; Biology; DNA methylation; Cancer research; Methylation; Cancer; MLH1; CpG site; Colorectal cancer; Genetics; DNA mismatch repair; Gene; Allele; Microsatellite; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115642,0.0001928785,0.0001991957,0.000510362,0.0001296192,0.0002443122,0.0002431132,0.0002169497,0.001296513],"category_scores_gemma":[0.0004854741,0.0001773992,0.0001444939,0.0002359618,0.0002832386,0.0003552862,0.0002625195,0.0002836867,0.0002254043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988308,"about_ca_system_score_gemma":0.0001381246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007883196,"about_ca_topic_score_gemma":0.000899506,"domain_scores_codex":[0.9998968,0.0000210359,0.00001088299,0.00002964318,0.00001794975,0.00002364846],"domain_scores_gemma":[0.9997897,0.00003214721,0.00008111689,0.00003494319,0.00002303012,0.00003914029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006391261,0.0000238148,0.03609198,0.00007387715,0.00003381649,0.0005192316,0.00009833978,0.0001199198,0.9569027,0.0005038434,0.00005838749,0.004934994],"study_design_scores_gemma":[0.00003917047,0.0003975206,0.446536,0.00001317031,0.0001092,0.004644542,0.0002451149,0.001521574,0.5417907,0.001427454,0.003250962,0.00002466256],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964967,0.001113632,0.001376477,0.00006881957,0.00001074074,0.000005290488,0.0001313303,0.0000547775,0.0007422288],"genre_scores_gemma":[0.9987946,0.0001748661,0.0003486118,0.00001080458,0.000004910123,0.000002461273,0.0000870058,0.000004802889,0.0005719641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296513,"threshold_uncertainty_score":0.004337311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013860810196407,"score_gpt":0.2647510750624652,"score_spread":0.2546124669605011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}