{"id":"W1967362046","doi":"10.1038/modpathol.3800996","title":"WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer","year":2007,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Gary Bennett Family Fund; National Cancer Institute; Entertainment Industry Foundation","keywords":"Microsatellite instability; Biology; DNA methylation; Cancer research; Methylation; Cancer; MLH1; CpG site; Colorectal cancer; Genetics; DNA mismatch repair; Gene; Allele; Microsatellite; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007063163,0.0001939222,0.0002332252,0.0001115164,0.00007532638,0.00002372634,0.00008463439,0.0003317185,0.00001780623],"category_scores_gemma":[0.000118663,0.0001872766,0.00004498294,0.0001123673,0.000106703,0.00000908556,0.00008297259,0.0001376379,0.000001959714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003908465,"about_ca_system_score_gemma":0.00005550703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009128395,"about_ca_topic_score_gemma":0.003267403,"domain_scores_codex":[0.9984747,0.0001771046,0.00036314,0.0005492361,0.0001020048,0.0003338033],"domain_scores_gemma":[0.9994115,0.00004656677,0.0001323556,0.0002065272,0.0001245635,0.00007851952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384544,0.00006915531,0.1903024,0.00001973425,0.00001519999,0.000006573145,0.0006800949,0.00007053232,0.7889116,0.00003021688,0.000001685569,0.01975431],"study_design_scores_gemma":[0.000670374,0.000167848,0.4702302,0.000005113674,0.00001490015,0.000004388464,0.00001638617,0.0007125618,0.525718,0.002122514,0.0001688172,0.0001689602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686596,0.003948235,0.02657476,0.00007309626,0.0001866996,0.0003572013,0.00003662976,0.00001301956,0.0001507936],"genre_scores_gemma":[0.9984372,0.0003431556,0.0008083206,0.00007764857,0.0001060785,0.00003624003,0.0001207584,0.00002545643,0.00004508799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2799278,"threshold_uncertainty_score":0.7636919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013860810196407,"score_gpt":0.2647510750624652,"score_spread":0.2546124669605011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}