{"id":"W1967375871","doi":"10.1016/j.brainres.2010.06.011","title":"Characterization of the 3xTg-AD mouse model of Alzheimer's disease: Part 2. Behavioral and cognitive changes","year":2010,"lang":"en","type":"article","venue":"Brain Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":231,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Cognition; Neuroscience; Anxiety; Psychology; Disease; Genetically modified mouse; Alzheimer's disease; Transgene; Medicine; Psychiatry; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000518402,0.000116793,0.0002145064,0.0001773514,0.0001370107,0.00001717996,0.0001242,0.00007793916,0.0001070247],"category_scores_gemma":[0.000317304,0.00008031709,0.00007014342,0.0002688941,0.0007524442,0.00008285289,0.0001946639,0.0003642742,0.000007370877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001096562,"about_ca_system_score_gemma":0.0004135592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005212463,"about_ca_topic_score_gemma":0.00004742309,"domain_scores_codex":[0.9980917,0.0001729994,0.0001730156,0.000262523,0.0009350844,0.0003646644],"domain_scores_gemma":[0.9984218,0.000139633,0.00006881635,0.0003779762,0.0005884066,0.0004033774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002073569,0.002892728,0.09235334,0.0002938273,0.002293807,0.00003588126,0.0008622378,5.449463e-7,0.877793,0.0005255637,0.0004555811,0.0204199],"study_design_scores_gemma":[0.004107984,0.0009070882,0.5744856,0.0004127068,0.001059609,0.000006465389,0.0003964819,0.002670787,0.4151228,0.0003924868,0.0002027331,0.0002352301],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942377,0.000795,0.000004661962,0.002900616,0.00002597754,0.001142841,0.0007446067,0.0000131393,0.000135432],"genre_scores_gemma":[0.9989102,0.0001709577,0.00003112527,0.00005331275,0.00004740974,0.0001398932,0.000175154,0.000025269,0.0004467169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4821323,"threshold_uncertainty_score":0.3275236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1190849408997277,"score_gpt":0.4039316999933658,"score_spread":0.2848467590936382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}