{"id":"W1967406345","doi":"10.1056/nejmoa1006565","title":"Homozygous <i>BUB1B</i> Mutation and Susceptibility to Gastrointestinal Neoplasia","year":2010,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McGill University and Génome Québec Innovation Centre; Jewish General Hospital; McGill University","funders":"","keywords":"Aneuploidy; Adenomatous polyposis coli; Medicine; Mutation; Germline mutation; Genetics; Familial adenomatous polyposis; Gene mutation; Cancer research; Biology; Cancer; Gene; Colorectal cancer; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914287,0.0005827869,0.000307661,0.0009248357,0.0006672096,0.0003975234,0.0001902173,0.0006834532,0.003674251],"category_scores_gemma":[0.001039717,0.0002204577,0.0002018457,0.0005140645,0.0003896076,0.0002300667,0.0002690697,0.00035632,0.0004675145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871646,"about_ca_system_score_gemma":0.0001676078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001590048,"about_ca_topic_score_gemma":0.001209505,"domain_scores_codex":[0.9998672,0.00002734637,0.00001350757,0.00003380957,0.00002152884,0.00003660968],"domain_scores_gemma":[0.9995841,0.0001098615,0.0001062543,0.00001946505,0.00002312119,0.000157181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00128303,0.0004694869,0.6108087,0.00007197468,0.0001400599,0.31981,0.0008346824,0.0006416701,0.05110773,0.00151606,0.002185176,0.01113149],"study_design_scores_gemma":[0.0001066207,0.0009262189,0.3693582,0.00004159303,0.0001589911,0.6185382,0.000376314,0.001089167,0.005377484,0.0006475807,0.003344158,0.00003540396],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971442,0.0002757562,0.0001358335,0.0001857705,0.00001333577,0.00001094826,0.00007695652,0.00001799644,0.002139274],"genre_scores_gemma":[0.999189,0.00009606118,0.0001111489,0.00004701361,0.00003100879,0.000003520967,0.00005564946,0.000005064219,0.0004616746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003674251,"threshold_uncertainty_score":0.01229155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01147868539904341,"score_gpt":0.2785216902312411,"score_spread":0.2670430048321977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}