{"id":"W1967427535","doi":"10.1021/ol005817b","title":"Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues","year":2000,"lang":"en","type":"article","venue":"Organic Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Polyamine; Polyamide; Yield (engineering); Venom; Borane; Combinatorial chemistry; Reduction (mathematics); Solid-phase synthesis; Organic chemistry; Biochemistry; Peptide; Materials science; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126336,0.0004077391,0.0002891399,0.0001809237,0.0002220055,0.0001990123,0.0003253142,0.0003370439,0.00277231],"category_scores_gemma":[0.0001519498,0.0001962478,0.0002581632,0.0003328609,0.0001943723,0.000250508,0.00030175,0.0007850631,0.001462381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002458411,"about_ca_system_score_gemma":0.0004223144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004021426,"about_ca_topic_score_gemma":0.0009371932,"domain_scores_codex":[0.9998852,0.00001305244,0.000009252713,0.00001867962,0.00004829413,0.00002542346],"domain_scores_gemma":[0.9998945,0.00001894955,0.00002734023,0.00001566948,0.00001954831,0.00002404218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008563587,0.00005710866,0.00002575169,0.0001579186,0.00001049244,0.0001488957,0.00006043606,0.0003109601,0.9917892,0.0007043026,0.0001458381,0.006503508],"study_design_scores_gemma":[0.00003472176,0.0003911059,0.0002465992,0.00000867794,0.00001176989,0.0002111656,0.00001709563,0.0004265599,0.9916993,0.0001741725,0.006769053,0.000009596192],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8542542,0.00899232,0.1053833,0.0003819544,0.0002785546,0.0007966097,0.002785986,0.0006855126,0.02644153],"genre_scores_gemma":[0.9019509,0.008944138,0.06867722,0.0001477412,0.00005737567,0.0005690021,0.002565012,0.0001814244,0.01690717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00277231,"threshold_uncertainty_score":0.009274244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06277751170277976,"score_gpt":0.3482975552848504,"score_spread":0.2855200435820706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}