{"id":"W1967449617","doi":"10.1021/bi035234k","title":"Lipid-Induced Conformational Switch in the Membrane Binding Domain of CTP:Phosphocholine Cytidylyltransferase:  A Circular Dichroism Study","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Phosphocholine; Circular dichroism; Chemistry; Biophysics; Protein secondary structure; Lipid bilayer; Phosphatidylglycerol; Vesicle; Lysophosphatidylcholine; Helix (gastropod); C2 domain; Peptide; Biochemistry; Phosphatidylcholine; Phospholipid; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005587199,0.0002557111,0.0002504396,0.00004967548,0.00008575951,0.000026347,0.0003755075,0.0002265044,0.00006389269],"category_scores_gemma":[0.00009724819,0.0002002749,0.0001343004,0.000245927,0.00007287451,0.000007643065,0.00003387495,0.0002176496,0.000003855465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002580514,"about_ca_system_score_gemma":0.0002146619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002793194,"about_ca_topic_score_gemma":0.00001079433,"domain_scores_codex":[0.9983927,0.00009816619,0.0004673477,0.0003743399,0.0003618145,0.0003056093],"domain_scores_gemma":[0.999125,0.000023232,0.0001152492,0.0005803124,0.00008256885,0.00007363833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005537727,0.0003241458,0.003213672,0.00008300084,0.00004032179,0.00001113587,0.0004107299,0.000005425557,0.9956796,0.00004059766,0.00004930568,0.00008664534],"study_design_scores_gemma":[0.001944352,0.000153788,0.001266743,0.00001777337,0.00004387336,0.00008068061,0.001923055,0.000001818168,0.9932542,0.000008469297,0.001064444,0.0002407666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998015,0.0001095719,0.00004789471,0.00006216766,0.0001477902,0.0004402677,0.00004795162,0.000009433673,0.001119942],"genre_scores_gemma":[0.9991677,0.00001777803,0.0001137033,0.0001420886,0.0001858617,0.00005766592,0.0001971524,0.00002085962,0.00009722453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002425406,"threshold_uncertainty_score":0.8166973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122311067641466,"score_gpt":0.2556054610559691,"score_spread":0.2443823503795544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}