{"id":"W1967449617","doi":"10.1021/bi035234k","title":"Lipid-Induced Conformational Switch in the Membrane Binding Domain of CTP:Phosphocholine Cytidylyltransferase:  A Circular Dichroism Study","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Phosphocholine; Circular dichroism; Chemistry; Biophysics; Protein secondary structure; Lipid bilayer; Phosphatidylglycerol; Vesicle; Lysophosphatidylcholine; Helix (gastropod); C2 domain; Peptide; Biochemistry; Phosphatidylcholine; Phospholipid; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033377,0.0001630879,0.0000873446,0.00006325694,0.00008731546,0.0001000198,0.0001262053,0.0001479107,0.0004747253],"category_scores_gemma":[0.0001222363,0.00007557123,0.0001350116,0.0000878333,0.0001510641,0.0001062424,0.00008288884,0.0003207343,0.0001260709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002020005,"about_ca_system_score_gemma":0.00007573442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790602,"about_ca_topic_score_gemma":0.0003047635,"domain_scores_codex":[0.9999555,0.000008277506,0.000003199427,0.00001151679,0.00001056491,0.00001084548],"domain_scores_gemma":[0.9999231,0.00002099665,0.00002175251,0.000005383497,0.00001121867,0.0000176642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006833996,0.00001795622,0.0002005073,0.00001084853,0.000002953986,0.00003610221,0.00001719982,0.00005990545,0.9992203,0.0000242886,0.000009172669,0.0003323179],"study_design_scores_gemma":[0.00001114266,0.0001261448,0.005130019,0.000002324567,0.000007732117,0.0001525128,0.0000225097,0.001382791,0.9927429,0.0000233283,0.0003941391,0.000004461618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987483,0.0001583172,0.0007742298,0.00002050998,0.000002821926,0.000006276918,0.00005155658,0.00000564124,0.0002322604],"genre_scores_gemma":[0.9986921,0.0001281732,0.0006475298,0.00002485542,0.00000226905,0.00000764181,0.000115764,0.000005363912,0.0003763778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004790602,"threshold_uncertainty_score":0.001588106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122311067641466,"score_gpt":0.2556054610559691,"score_spread":0.2443823503795544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}