{"id":"W1967477962","doi":"10.1371/journal.pmed.0030094","title":"Enrolling Women into HIV Preventive Vaccine Trials: An Ethical Imperative but a Logistical Challenge","year":2006,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; McMaster University","funders":"Ontario HIV Treatment Network","keywords":"HIV vaccine; Human immunodeficiency virus (HIV); Medicine; AIDS Vaccines; Pre-exposure prophylaxis; Clinical trial; Family medicine; Alternative medicine; Virology; Environmental health; Vaccine trial; Men who have sex with men; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.02634297,0.0004302523,0.002121995,0.0003085992,0.0002207919,0.00002918561,0.0004332096,0.001439284,0.002780232],"category_scores_gemma":[0.1649971,0.0002893788,0.0001889193,0.0004349899,0.000956558,0.0001059629,0.0002245554,0.006851944,0.0001837235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004915323,"about_ca_system_score_gemma":0.0006808991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002770002,"about_ca_topic_score_gemma":0.0002445898,"domain_scores_codex":[0.9915065,0.00181407,0.00206235,0.001070664,0.00259386,0.0009525709],"domain_scores_gemma":[0.9573191,0.03888611,0.0003342842,0.001013727,0.001384594,0.001062209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.03705943,0.02376837,0.01335524,0.007853418,0.004772121,0.006289279,0.06296718,0.00007789891,0.2755278,0.5174148,0.02200505,0.02890934],"study_design_scores_gemma":[0.04427556,0.02902856,0.007770942,0.006306593,0.00163595,0.0001380211,0.01458955,0.01097991,0.0132759,0.8645129,0.006070876,0.001415241],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7298431,0.002469519,0.01060326,0.2324156,0.000562556,0.003139316,0.00004065779,0.0004568281,0.02046908],"genre_scores_gemma":[0.9834698,0.001099235,0.002709208,0.002630859,0.005379602,0.0002950937,0.0001269647,0.00008201775,0.004207205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3470981,"threshold_uncertainty_score":0.9999558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4710769144362194,"score_gpt":0.573731512867316,"score_spread":0.1026545984310967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}