{"id":"W1967494982","doi":"10.1172/jci10564","title":"Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice","year":2001,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":537,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University; Women's Health Research Institute","funders":"Canadian Arthritis Network; Medical Research Council; National Institute on Aging; National Institutes of Health; Medical Research Council Canada; Shriners Hospitals for Children","keywords":"Collagenase; Cartilage; Osteoarthritis; Matrix metalloproteinase; Hyaline; Proteoglycan; Synovitis; Hyaline cartilage; Transgene; Pathology; Metalloproteinase; Type II collagen; MMP1; Chemistry; Cell biology; Biology; Gene expression; Medicine; Arthritis; Immunology; Internal medicine; Anatomy; Articular cartilage; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007303898,0.0008646383,0.0005748746,0.001434345,0.0004063431,0.0006822502,0.0006209089,0.001146642,0.002689324],"category_scores_gemma":[0.0003800405,0.0007507288,0.0006461347,0.0004594773,0.0009081288,0.0004785656,0.0004360086,0.002046619,0.001305131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007108082,"about_ca_system_score_gemma":0.0004981642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009875854,"about_ca_topic_score_gemma":0.001727242,"domain_scores_codex":[0.9992121,0.0001330772,0.0001134569,0.0001360309,0.0002051474,0.0002001549],"domain_scores_gemma":[0.99898,0.0001658546,0.0003282255,0.0001026723,0.00007405331,0.0003491401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000359502,0.0002400835,0.0001946137,0.00004639289,0.000008484227,0.0001419565,0.00003989675,0.00004630108,0.9974071,0.0002743661,0.00006607777,0.001175225],"study_design_scores_gemma":[0.0003475228,0.002190236,0.004661661,0.00004877625,0.00006832871,0.0008314003,0.00006953347,0.001110475,0.9858075,0.0002152521,0.004633536,0.00001576636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851224,0.001905503,0.007254899,0.0003515462,0.00008961603,0.0002800278,0.001368499,0.0006061183,0.003021412],"genre_scores_gemma":[0.9686995,0.002376574,0.01150209,0.0002211795,0.00006453845,0.000456685,0.002239815,0.0002604382,0.01417925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002689324,"threshold_uncertainty_score":0.008996725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06738610853385885,"score_gpt":0.3666802277330138,"score_spread":0.2992941191991549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}