{"id":"W1967517562","doi":"10.1038/nbt787","title":"Site-specific cassette exchange and germline transmission with mouse ES cells expressing φC31 integrase","year":2003,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute on Drug Abuse","keywords":"Integrase; Recombinase; Integrases; Site-specific recombination; FLP-FRT recombination; Biology; Homologous recombination; Cre recombinase; Genetics; Schizosaccharomyces pombe; Cre-Lox recombination; Genome; DNA; Computational biology; Saccharomyces cerevisiae; Recombination; Gene; Genetic recombination; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001734169,0.001477247,0.001049904,0.002144326,0.001027706,0.00113317,0.002422316,0.002869375,0.007602897],"category_scores_gemma":[0.0007229935,0.001414362,0.00159539,0.001513833,0.001660571,0.0007925368,0.001173148,0.004444082,0.003424262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101769,"about_ca_system_score_gemma":0.0008468525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001781113,"about_ca_topic_score_gemma":0.002747838,"domain_scores_codex":[0.9978428,0.0003508633,0.0003302647,0.0005423746,0.0005301522,0.0004036074],"domain_scores_gemma":[0.9984444,0.0003711202,0.0003673439,0.0004053334,0.0001205101,0.0002913931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002539777,0.0001093315,0.00009756131,0.00004678687,0.00001808935,0.0001590786,0.00007585052,0.0001096893,0.9955219,0.00170032,0.0002535234,0.001653915],"study_design_scores_gemma":[0.0001254583,0.000152845,0.0006729406,0.00001245578,0.00002942231,0.0003276818,0.00002321084,0.0008171996,0.9923766,0.0001899889,0.005253415,0.00001871085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8002539,0.002726351,0.1432648,0.002111676,0.001330705,0.0053621,0.01204744,0.004659298,0.02824372],"genre_scores_gemma":[0.8505693,0.002240098,0.07567453,0.0004547455,0.0001088019,0.001943513,0.007365701,0.001370033,0.06027326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007602897,"threshold_uncertainty_score":0.02543426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003863518385209464,"score_gpt":0.241207306388595,"score_spread":0.2373437880033855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}