{"id":"W1967517562","doi":"10.1038/nbt787","title":"Site-specific cassette exchange and germline transmission with mouse ES cells expressing φC31 integrase","year":2003,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Institute on Drug Abuse","keywords":"Integrase; Recombinase; Integrases; Site-specific recombination; FLP-FRT recombination; Biology; Homologous recombination; Cre recombinase; Genetics; Schizosaccharomyces pombe; Cre-Lox recombination; Genome; DNA; Computational biology; Saccharomyces cerevisiae; Recombination; Gene; Genetic recombination; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008749408,0.000212777,0.0001618109,0.0001045567,0.00006878882,0.00001900698,0.0001134023,0.00103832,0.00002006457],"category_scores_gemma":[0.0000204734,0.0001710995,0.0000375319,0.0001164319,0.0001150423,0.000002692032,0.00004090789,0.0004959229,0.000002195303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008529187,"about_ca_system_score_gemma":0.00001631255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002576552,"about_ca_topic_score_gemma":0.00001612791,"domain_scores_codex":[0.9990555,0.0000252246,0.0001265363,0.0004426283,0.00007956744,0.0002705418],"domain_scores_gemma":[0.9994959,0.00001022728,0.00003853731,0.0003491161,0.0000336743,0.00007249659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004160978,0.00002636539,0.00004839691,0.00002856166,0.00001709905,0.00001837131,0.00003132952,0.00002933189,0.9892957,0.0001645086,0.001190517,0.009108267],"study_design_scores_gemma":[0.0003763558,0.0001431684,0.00002250549,0.00001603769,0.00001012291,0.00006570733,0.00003523686,0.00002395443,0.6969941,0.00001012365,0.3021416,0.0001610899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9369683,0.02490163,0.03719427,0.0004082728,0.000112858,0.0001676131,0.00001798188,0.00007479827,0.0001543206],"genre_scores_gemma":[0.9823644,0.002992392,0.01394906,0.0001398058,0.00007124503,0.00001035097,0.00003870022,0.00003691418,0.0003971111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3009511,"threshold_uncertainty_score":0.8008474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003863518385209464,"score_gpt":0.241207306388595,"score_spread":0.2373437880033855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}