{"id":"W1967536924","doi":"10.1371/journal.pone.0012707","title":"Akt Deficiency Attenuates Muscle Size and Function but Not the Response to ActRIIB Inhibition","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"World Anti-Doping Agency; National Institutes of Health; Acceleron; National Institute of Diabetes and Digestive and Kidney Diseases; University of Pennsylvania","keywords":"AKT1; AKT2; Skeletal muscle; Protein kinase B; Myostatin; Sarcopenia; Muscle hypertrophy; Endocrinology; Internal medicine; Biology; Myosin; Chemistry; Signal transduction; Cell biology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130699,0.00007993347,0.00006854149,0.000017445,0.0001429457,0.00001438929,0.00006254428,0.0001050683,0.00003521343],"category_scores_gemma":[0.0005348268,0.00006254747,0.00002091539,0.00005562177,0.0000825765,0.000003964722,0.00006438782,0.0001095407,0.00002861533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002206759,"about_ca_system_score_gemma":0.00002320217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000142891,"about_ca_topic_score_gemma":0.00004275098,"domain_scores_codex":[0.9994181,0.0000629425,0.0000841133,0.0002160738,0.00007779381,0.0001409335],"domain_scores_gemma":[0.999572,0.00007110422,0.00003027094,0.0002271643,0.00005032118,0.00004912827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001111394,0.0002075051,0.0002870283,0.000007722821,0.00001502836,2.456068e-7,0.0000416723,0.000001381748,0.9973817,0.00004106088,0.0001954008,0.0007098093],"study_design_scores_gemma":[0.000446305,0.0005593018,0.09061677,0.000007301448,0.00003202221,0.000001119381,0.00008208104,0.00001094779,0.9069097,0.0002539567,0.0009658626,0.0001146372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973776,0.00006311884,0.0000375329,0.001993071,0.00004741811,0.0001714277,0.00001063036,0.00001269444,0.0002864684],"genre_scores_gemma":[0.9978358,0.00002146262,0.0001251987,0.001544883,0.0001037678,0.000035821,0.0000173127,0.00000869627,0.0003071127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09047206,"threshold_uncertainty_score":0.2550612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450587398047081,"score_gpt":0.2145683219582848,"score_spread":0.200062447977814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}