{"id":"W1967582474","doi":"10.1016/j.bcp.2008.11.004","title":"Activation and modulation of 72kDa matrix metalloproteinase-2 by peroxynitrite and glutathione","year":2008,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":235,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"University of Alberta","keywords":"Peroxynitrite; Glutathione; Chemistry; Biochemistry; Oxidative stress; Zymogen; Peroxynitrous acid; Cysteine; Matrix metalloproteinase; Enzyme; Superoxide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007844353,0.0001135878,0.000137428,0.00003246808,0.00005756694,0.000002860753,0.00005141562,0.0001732778,0.00001758313],"category_scores_gemma":[0.00003346958,0.0001130218,0.0000312433,0.00005178033,0.000144769,0.000007467278,0.00008050956,0.00007391403,0.000001129726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007317813,"about_ca_system_score_gemma":0.00002249028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206958,"about_ca_topic_score_gemma":5.507577e-8,"domain_scores_codex":[0.9993162,0.00004450846,0.000166451,0.0002600354,0.00007762271,0.0001351793],"domain_scores_gemma":[0.9996976,0.00001058293,0.00007951754,0.00008025969,0.0000536836,0.00007832388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001416224,0.00006109529,0.00004439239,0.00002296981,0.00003309517,0.000001100457,0.0000150621,0.000001001146,0.9844663,0.00002557589,0.01504437,0.0001434327],"study_design_scores_gemma":[0.000887182,0.0002073286,0.0001629218,0.000004491916,0.00002202062,0.00003111248,0.000006850677,0.0002075347,0.9963254,0.0001217148,0.001914587,0.0001088699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995083,0.003132293,0.001264214,0.0001655383,0.0000467871,0.0002348782,0.00001958976,0.00000984337,0.00004383926],"genre_scores_gemma":[0.9979962,0.0005808636,0.0008404932,0.0001969423,0.0001253575,0.00002905527,0.0001055367,0.00001119032,0.0001143914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01312978,"threshold_uncertainty_score":0.4608894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008974917415165677,"score_gpt":0.2555130556003872,"score_spread":0.2465381381852216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}