{"id":"W1967584222","doi":"10.1021/tx034195a","title":"Tolerance Induced by Low Dose<scp>d</scp>-Penicillamine in the Brown Norway Rat Model of Drug-Induced Autoimmunity Is Immune-Mediated","year":2003,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Penicillamine; Autoimmunity; Immune system; Pharmacology; Immune tolerance; Immunology; Medicine; Splenocyte; Drug; Cytokine; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.003402402,0.000440321,0.00102526,0.0005014206,0.0002230086,0.00002215469,0.001783144,0.001460939,0.0003429338],"category_scores_gemma":[0.003571739,0.0003543085,0.0001780372,0.001444429,0.001586318,0.0001271528,0.0004652675,0.004122291,0.0004367994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997514,"about_ca_system_score_gemma":0.0005978781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003940795,"about_ca_topic_score_gemma":0.0001027536,"domain_scores_codex":[0.9928974,0.002971269,0.001174074,0.0008133958,0.0002447532,0.001899098],"domain_scores_gemma":[0.993066,0.005208596,0.0002390546,0.001131252,0.0002811241,0.00007401026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001967294,0.0016304,0.0002265122,0.00005681346,0.00005745627,0.00001863826,0.002084692,0.00001287561,0.9890906,0.0007535451,0.005374347,0.0004973419],"study_design_scores_gemma":[0.004550416,0.000373671,0.0002794096,0.00005806294,0.000009524985,0.00003093897,0.001169342,0.0001897649,0.9862068,0.000916655,0.006029957,0.0001854075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892132,0.002964119,0.000003451494,0.001342425,0.000367591,0.0008710194,0.00004020775,0.00003461695,0.005163408],"genre_scores_gemma":[0.9965247,0.0003552751,0.00003118113,0.0004977095,0.0000168566,0.0002586312,0.0001249939,0.0000409578,0.0021497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007311533,"threshold_uncertainty_score":0.9998909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936191617552864,"score_gpt":0.3088052445358548,"score_spread":0.2594433283603261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}