{"id":"W1967586503","doi":"10.1016/j.pharmthera.2015.04.001","title":"Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation","year":2015,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Genome Canada","keywords":"Histone methyltransferase; DNA demethylation; Histone methylation; Epigenomics; Epigenetics; Methyltransferase; Histone; Chromatin; Cancer epigenetics; Biology; DNA methylation; Histone code; Genetics; Computational biology; DNA; Methylation; Nucleosome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007392608,0.0009771683,0.001542618,0.001840783,0.0002560474,0.0009590248,0.0008873601,0.001209771,0.005009381],"category_scores_gemma":[0.0007765515,0.000368589,0.0004959119,0.002075109,0.0006617776,0.00122752,0.000864056,0.002203014,0.002355567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008280386,"about_ca_system_score_gemma":0.001014658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007530696,"about_ca_topic_score_gemma":0.002464375,"domain_scores_codex":[0.9997988,0.00004080423,0.00002308662,0.00003039458,0.00008270761,0.00002412485],"domain_scores_gemma":[0.999732,0.0001282949,0.00003901748,0.00001136217,0.00006277792,0.00002656347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007913753,0.00007624792,0.0001326288,0.008631234,0.0001092509,0.000184101,0.00003183504,0.0005570243,0.003481739,0.006024774,0.06057336,0.9201187],"study_design_scores_gemma":[0.0000281301,0.00009235547,0.0004979827,0.001244021,0.00009560637,0.0007062434,0.00002354791,0.0001861977,0.001052552,0.003034428,0.9930206,0.00001822226],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001101669,0.9967398,0.0004421772,0.0006719233,0.0005283167,0.000009614559,0.00002850599,0.00001457148,0.001454893],"genre_scores_gemma":[0.000854562,0.9958724,0.000351355,0.0005307817,0.0005524158,0.00001311467,0.00004436448,0.00000250675,0.001778479],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005009381,"threshold_uncertainty_score":0.01675808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05933012450344433,"score_gpt":0.3854110461801277,"score_spread":0.3260809216766833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}