{"id":"W1967603104","doi":"10.1016/j.bmcl.2014.12.063","title":"Biofilm inhibition of linezolid-like Schiff bases: Synthesis, biological activity, molecular docking and in silico ADME prediction","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Atlantic Canada Opportunities Agency; University of the Punjab","keywords":"ADME; Chemistry; Linezolid; Biofilm; Quorum sensing; IC50; Minimum inhibitory concentration; Docking (animal); Antibacterial activity; Combinatorial chemistry; In silico; Pseudomonas aeruginosa; Antibacterial agent; Ciprofloxacin; Stereochemistry; In vitro; Biochemistry; Bacteria; Antibiotics; Staphylococcus aureus; Biology; Vancomycin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004465186,0.0007788464,0.0007450617,0.0002632981,0.0002223125,0.0004663386,0.0006126551,0.0004287302,0.001314895],"category_scores_gemma":[0.0005348302,0.0003027058,0.0006822402,0.0002416165,0.0001331615,0.0002535375,0.0002559383,0.0007508318,0.0003058215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000715088,"about_ca_system_score_gemma":0.0005001325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002888533,"about_ca_topic_score_gemma":0.004558972,"domain_scores_codex":[0.9998833,0.00003408841,0.0000055625,0.00002362051,0.00003068521,0.00002270031],"domain_scores_gemma":[0.9998773,0.00003973366,0.00002817785,0.000009023972,0.0000280677,0.00001780949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002468333,0.0009190307,0.003556964,0.00140226,0.000447408,0.0007526337,0.0001310239,0.5331367,0.3811277,0.004570188,0.003069517,0.06841823],"study_design_scores_gemma":[0.0004593194,0.003671019,0.001218013,0.00006428293,0.0003416205,0.0002590098,0.00006350536,0.6833956,0.3047409,0.0005661453,0.005124484,0.00009614855],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631655,0.004986687,0.02579989,0.0003881205,0.0000601282,0.0001231723,0.00107167,0.0003422399,0.004062477],"genre_scores_gemma":[0.9777078,0.002080268,0.01793883,0.00005653984,0.000006431183,0.00005089016,0.0006361003,0.00002857686,0.001494539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002888533,"threshold_uncertainty_score":0.005743504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008216722290198607,"score_gpt":0.2120350063355552,"score_spread":0.2038182840453567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}