{"id":"W1967616002","doi":"10.1139/o99-069","title":"The phosphatase domains of LAR, CD45, and PTP1B: structural correlations with peptide-based inhibitors<sup>1</sup>","year":2000,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Merck Canada","keywords":"Protein tyrosine phosphatase; Phosphatase; Active site; DUSP6; Receptor tyrosine kinase; Enzyme; Chemistry; Biochemistry; Transmembrane protein; Topology (electrical circuits); Tyrosine kinase; Kinase; Biology; Receptor; Protein phosphatase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528135,0.0003056227,0.0002499474,0.0001256411,0.0001080533,0.0003877213,0.0003477853,0.0001911431,0.0007596815],"category_scores_gemma":[0.0002728257,0.0001423471,0.0001732347,0.000176458,0.0001733316,0.0002695192,0.0001672907,0.0004188869,0.0001541983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005026576,"about_ca_system_score_gemma":0.0001582194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221552,"about_ca_topic_score_gemma":0.0008413466,"domain_scores_codex":[0.9999049,0.00002295234,0.000004909847,0.00001666399,0.00003025006,0.00002034031],"domain_scores_gemma":[0.9999197,0.00002553986,0.00002683394,0.000004976227,0.000009458668,0.00001356099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001083601,0.0002140827,0.00299262,0.0002054175,0.00007388376,0.0003400712,0.000129395,0.04742337,0.928313,0.003586769,0.0004626093,0.01517508],"study_design_scores_gemma":[0.0001316078,0.0005510404,0.006377981,0.00002208341,0.00009620476,0.0004147127,0.00008936894,0.1186176,0.8661597,0.0006536124,0.006861073,0.00002497934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922902,0.002279837,0.003212177,0.00007248887,0.000005984337,0.00001722767,0.0001435111,0.00003852397,0.00194008],"genre_scores_gemma":[0.9943107,0.001209201,0.003571965,0.00003001025,0.000002494393,0.00001566508,0.0003889705,0.000008331018,0.000462576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221552,"threshold_uncertainty_score":0.003647089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003368823766791853,"score_gpt":0.2008839362814861,"score_spread":0.1975151125146942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}