{"id":"W1967628212","doi":"10.1089/scd.2009.0297","title":"Reduced Differentiation Efficiency of Murine Embryonic Stem Cells in Stirred Suspension Bioreactors","year":2009,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Arthritis Society; Stem Cell Network; University of Calgary","keywords":"Embryonic stem cell; Bioreactor; Cell biology; Biology; Chondrogenesis; Stem cell; Cellular differentiation; Regenerative medicine; Cell culture; Induced pluripotent stem cell; Leukemia inhibitory factor; Biochemistry; Botany; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002749295,0.000200725,0.0002447278,0.0001472247,0.00005926902,0.00002193618,0.000157454,0.0001356084,0.00001004928],"category_scores_gemma":[0.000002385361,0.0001766772,0.0000424211,0.0001579796,0.00003904569,0.00000605091,0.0001235085,0.00009153062,0.00000985106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004959427,"about_ca_system_score_gemma":0.0001508583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001129005,"about_ca_topic_score_gemma":0.00001996075,"domain_scores_codex":[0.998438,0.00007364478,0.000404827,0.0004457959,0.0002896769,0.0003480325],"domain_scores_gemma":[0.9994205,0.00001529955,0.0001314512,0.0002430436,0.00007767641,0.0001119795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008696903,0.0001762938,0.0008350065,0.00006544376,0.00001379548,0.000005459979,0.0001660405,0.00003939002,0.9870613,0.00000438156,0.0001619195,0.01138404],"study_design_scores_gemma":[0.000803384,0.0002324259,0.02087516,0.0000601113,0.000004562908,0.00000251366,0.0001283018,0.00009451413,0.9757627,0.000003518565,0.001830657,0.000202137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984391,0.0005563493,0.0001909303,0.00005682506,0.0001439037,0.0003740681,0.000006829769,0.000009091375,0.0002228608],"genre_scores_gemma":[0.997824,0.0004343637,0.0002802711,0.00001911663,0.00002058392,0.000007067166,0.00003275899,0.00001319824,0.001368626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02004015,"threshold_uncertainty_score":0.7204687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437048099779933,"score_gpt":0.238896477839474,"score_spread":0.2245259968416747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}