{"id":"W1967628212","doi":"10.1089/scd.2009.0297","title":"Reduced Differentiation Efficiency of Murine Embryonic Stem Cells in Stirred Suspension Bioreactors","year":2009,"lang":"en","type":"article","venue":"Stem Cells and Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Arthritis Society; Stem Cell Network; University of Calgary","keywords":"Embryonic stem cell; Bioreactor; Cell biology; Biology; Chondrogenesis; Stem cell; Cellular differentiation; Regenerative medicine; Cell culture; Induced pluripotent stem cell; Leukemia inhibitory factor; Biochemistry; Botany; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008804955,0.0003841333,0.0003975086,0.0004249808,0.0001242088,0.0005232976,0.0003633153,0.000319993,0.0005349577],"category_scores_gemma":[0.0005842255,0.0001562266,0.0002807412,0.0002613697,0.0001878827,0.0002808052,0.0002627391,0.0004725998,0.0005401867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630695,"about_ca_system_score_gemma":0.0002660867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008190926,"about_ca_topic_score_gemma":0.000911266,"domain_scores_codex":[0.9993203,0.0001380762,0.0001124865,0.0001375639,0.0002462364,0.00004540452],"domain_scores_gemma":[0.9995604,0.0001642281,0.00008890747,0.0000552482,0.00008642886,0.00004485761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003764265,0.00001115761,0.0002089836,0.00002133296,0.00000319993,0.0000193071,0.00001690509,0.00010415,0.9982044,0.00005358259,0.00001493379,0.001304423],"study_design_scores_gemma":[0.000003416678,0.0001284825,0.001216615,0.000004870707,0.00001178686,0.00005350586,0.00001031122,0.0008375238,0.9967445,0.00002237696,0.0009630968,0.000003490601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658354,0.003365534,0.0282251,0.0001097896,0.00006069225,0.00004918901,0.0003841627,0.0002753671,0.001694802],"genre_scores_gemma":[0.9687837,0.001946292,0.0240567,0.00006123727,0.00002107385,0.00006963447,0.001118198,0.0001022258,0.003841037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008804955,"threshold_uncertainty_score":0.004656553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437048099779933,"score_gpt":0.238896477839474,"score_spread":0.2245259968416747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}