{"id":"W1967632213","doi":"10.1007/s00125-014-3249-1","title":"TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6","year":2014,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"Canadian Institutes of Health Research; Servier","keywords":"TLR2; TLR4; Beta cell; Islet; Inflammation; Endocrinology; Biology; Internal medicine; Toll-like receptor; Pancreatic islets; Insulin; Receptor; Immunology; Innate immune system; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003006919,0.0002180163,0.0004766734,0.0001317025,0.0001162572,0.00004417678,0.00004273487,0.0001809928,0.00004706856],"category_scores_gemma":[0.0003778255,0.0001712728,0.00002690836,0.0001372754,0.0001046336,0.0001153677,0.00009478237,0.0001481928,0.00002427709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000227788,"about_ca_system_score_gemma":0.00001598006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002482294,"about_ca_topic_score_gemma":9.929566e-7,"domain_scores_codex":[0.9988116,0.0001069475,0.0002721027,0.0003683499,0.0001434759,0.0002975483],"domain_scores_gemma":[0.9990191,0.0002637823,0.0001058826,0.0002268475,0.00009413029,0.0002902477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001558103,0.00003689572,0.05254877,0.0001140683,0.00002680289,0.000005987369,0.0001792538,0.000001919429,0.9355102,0.00003113207,0.0007561903,0.010633],"study_design_scores_gemma":[0.00233824,0.0004686608,0.2098634,0.00006523168,0.00006700987,0.00001025097,0.00004777985,0.0005935683,0.7840974,0.0001014267,0.00217926,0.0001678408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965171,0.0007411415,0.0009375818,0.0007396174,0.0001017148,0.0004559347,0.00004409004,0.0001149668,0.0003478701],"genre_scores_gemma":[0.997153,0.0001634908,0.001640061,0.0006197447,0.0001164205,0.00003492453,0.00009076837,0.00001872545,0.0001628623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1573146,"threshold_uncertainty_score":0.69843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007091157002808063,"score_gpt":0.2240430835859897,"score_spread":0.2169519265831816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}