{"id":"W1967637444","doi":"10.1074/jbc.m202946200","title":"Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Fondation pour la Recherche Médicale; University of Alberta; Canadian Institutes of Health Research; Deutsches Krebsforschungszentrum","keywords":"Apoptosis; Tumor necrosis factor alpha; Biology; Flip; XIAP; Cell biology; Programmed cell death; Caspase 8; Kinase; Signal transduction; Glioma; Phosphorylation; Caspase; Cancer research; Molecular biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002554801,0.0002298716,0.0003282684,0.00004778763,0.0001043298,0.00005292603,0.0001146358,0.000387761,0.00009148823],"category_scores_gemma":[0.0000918552,0.0001835581,0.00009686861,0.0001049083,0.00003290708,0.00001447163,0.00008061446,0.0002660777,8.856358e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003391712,"about_ca_system_score_gemma":0.00001325954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006069947,"about_ca_topic_score_gemma":3.904673e-7,"domain_scores_codex":[0.9986246,0.00005699925,0.0005571361,0.0003501322,0.0001501399,0.0002609559],"domain_scores_gemma":[0.9992185,0.00003851478,0.0003766246,0.0001089731,0.00009552432,0.0001619036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003984919,0.00007062915,0.0008914967,0.00002756105,0.00002973876,0.0000102412,0.00005998648,0.000106656,0.9967501,0.000001840262,0.00004272597,0.001969167],"study_design_scores_gemma":[0.0008935478,0.0002350357,0.00410948,0.00007357855,0.00001798193,0.0001232139,0.00007838819,0.003416299,0.9906963,0.00004387951,0.00007683857,0.0002354927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982566,0.001308843,0.00007988439,0.00007987944,0.00006773273,0.0001025093,0.000009945277,0.000008256751,0.00008641429],"genre_scores_gemma":[0.9991115,0.0003325439,0.0002411354,0.0000436616,0.0001606629,0.000002224112,0.00002551741,0.00001600325,0.00006675535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006053843,"threshold_uncertainty_score":0.7485281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03588948435848231,"score_gpt":0.2439903326444616,"score_spread":0.2081008482859793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}