{"id":"W1967643491","doi":"10.1002/mds.20828","title":"Histamine H3 receptor agonists reduce <scp>L</scp>‐dopa–induced chorea, but not dystonia, in the MPTP‐lesioned nonhuman primate model of Parkinson's disease","year":2006,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"","keywords":"Dyskinesia; Chorea; Dystonia; MPTP; Histamine H3 receptor; Parkinson's disease; Basal ganglia; Striatum; Substantia nigra; Neuroscience; Agonist; Dopamine; Medicine; Psychology; Pharmacology; Internal medicine; Endocrinology; Receptor; Central nervous system; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685047,0.0006982573,0.0007945789,0.0005244819,0.0003401808,0.0003459986,0.000350524,0.0005645884,0.00204799],"category_scores_gemma":[0.0001964899,0.0003206591,0.0004089908,0.0002290535,0.0003428447,0.0003459916,0.0001969537,0.001097347,0.0005325587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004811372,"about_ca_system_score_gemma":0.0004712025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003942406,"about_ca_topic_score_gemma":0.01038002,"domain_scores_codex":[0.9998216,0.00003080058,0.00001982339,0.00002323266,0.00003931544,0.00006526457],"domain_scores_gemma":[0.999817,0.0000158778,0.00004320613,0.00001347812,0.00001652541,0.00009386982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001335553,0.0004481821,0.0001931553,0.00008287274,0.00002908336,0.000163231,0.00005380719,0.00008526677,0.9949626,0.00005915591,0.000190458,0.002396756],"study_design_scores_gemma":[0.0004046444,0.01453076,0.01914971,0.00002634467,0.0001191115,0.0006721649,0.0001682336,0.001998668,0.9599479,0.0001005514,0.002855591,0.00002619158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961397,0.001168545,0.0003046373,0.000134822,0.00003505671,0.00005240608,0.0003980612,0.0001503208,0.001616427],"genre_scores_gemma":[0.9940087,0.00101056,0.0007864541,0.0001226994,0.00002738917,0.00007804234,0.0007859258,0.00003736522,0.003142851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003942406,"threshold_uncertainty_score":0.007838905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183808262711531,"score_gpt":0.221520377292904,"score_spread":0.2096822946657887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}