{"id":"W1967643491","doi":"10.1002/mds.20828","title":"Histamine H3 receptor agonists reduce <scp>L</scp>‐dopa–induced chorea, but not dystonia, in the MPTP‐lesioned nonhuman primate model of Parkinson's disease","year":2006,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"","keywords":"Dyskinesia; Chorea; Dystonia; MPTP; Histamine H3 receptor; Parkinson's disease; Basal ganglia; Striatum; Substantia nigra; Neuroscience; Agonist; Dopamine; Medicine; Psychology; Pharmacology; Internal medicine; Endocrinology; Receptor; Central nervous system; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003869546,0.0003648913,0.0004286031,0.0001884464,0.0002650055,0.00002789041,0.0005145182,0.0001486051,0.0002177838],"category_scores_gemma":[0.00005697544,0.0002962803,0.000168651,0.000206245,0.000276836,0.00008725548,0.0001126584,0.0002861075,0.00007465088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000131933,"about_ca_system_score_gemma":0.0001049154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002156996,"about_ca_topic_score_gemma":0.001247431,"domain_scores_codex":[0.9978592,0.0001736594,0.0006341034,0.0005497421,0.0001635287,0.0006197594],"domain_scores_gemma":[0.9988053,0.0001272318,0.0003123721,0.0006501123,0.00005955079,0.00004546909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004056782,0.002523848,0.004902765,0.0001984961,0.000100747,0.0000105032,0.001393206,0.0007943588,0.94082,0.007443466,0.03913796,0.002268977],"study_design_scores_gemma":[0.02113477,0.001647744,0.1899535,0.0004044455,0.0004998486,0.00000230354,0.005326231,0.002916339,0.3823555,0.01792037,0.3761781,0.001660919],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990263,0.001230697,0.0001533099,0.001193057,0.0003068881,0.0008029281,0.0002453141,0.00005230716,0.005752521],"genre_scores_gemma":[0.9835119,0.0002461807,0.0001139395,0.0008695987,0.0000323976,0.0001543952,0.0006718006,0.00004055799,0.0143592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5584645,"threshold_uncertainty_score":0.9999489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183808262711531,"score_gpt":0.221520377292904,"score_spread":0.2096822946657887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}