{"id":"W1967655002","doi":"10.1074/jbc.m110.115295","title":"PTP1B Targets the Endosomal Sorting Machinery","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; University at Albany; McGill University","keywords":"Endosome; Endocytic cycle; Phosphorylation; Cell biology; Receptor tyrosine kinase; Signal transduction; Dephosphorylation; Biology; Tyrosine phosphorylation; Protein kinase B; Receptor; Endocytosis; Biochemistry; Intracellular; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004438599,0.0001541008,0.0001780087,0.000008271108,0.0000949911,0.0000285231,0.000516658,0.0002300994,0.0001554632],"category_scores_gemma":[0.001274327,0.00008435669,0.0002011851,0.00005102507,0.0002006997,0.000004465655,0.0001803269,0.0005513792,0.000004185221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006075309,"about_ca_system_score_gemma":0.00006718004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002151335,"about_ca_topic_score_gemma":9.590415e-7,"domain_scores_codex":[0.999016,0.00003499409,0.0003913649,0.0001747028,0.0001454352,0.0002375192],"domain_scores_gemma":[0.9990677,0.00004898848,0.0003875988,0.0002650473,0.0001166864,0.0001139679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009181934,0.00004864326,0.005599144,0.00000735165,0.00003293494,0.0000219914,0.000003605172,0.000005138153,0.9907604,0.00006073619,0.001626741,0.001741525],"study_design_scores_gemma":[0.000299258,0.0001237323,0.002904648,0.000006946882,0.0000110197,0.000511652,0.00001789595,0.000005870053,0.9703417,0.0003681137,0.0252925,0.0001166244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930646,0.004964703,0.0002149329,0.0005170715,0.0002271967,0.00005787287,0.00001765915,0.000007577288,0.000928433],"genre_scores_gemma":[0.9965559,0.0001255061,0.001378372,0.0003080655,0.001464472,0.000004371222,0.00002837969,0.00001025934,0.0001246754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02366576,"threshold_uncertainty_score":0.3439966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092305893727813,"score_gpt":0.2478386061751241,"score_spread":0.236915547237846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}