{"id":"W1967655002","doi":"10.1074/jbc.m110.115295","title":"PTP1B Targets the Endosomal Sorting Machinery","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; University at Albany; McGill University","keywords":"Endosome; Endocytic cycle; Phosphorylation; Cell biology; Receptor tyrosine kinase; Signal transduction; Dephosphorylation; Biology; Tyrosine phosphorylation; Protein kinase B; Receptor; Endocytosis; Biochemistry; Intracellular; Phosphatase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385307,0.0003806407,0.0002470187,0.0002541111,0.0002727952,0.0005037697,0.0001800258,0.0003660928,0.002479283],"category_scores_gemma":[0.0001426504,0.0001672987,0.0002770688,0.0002132799,0.0001664219,0.0002883163,0.0003137777,0.0007474921,0.00139732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005727087,"about_ca_system_score_gemma":0.0003094572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008104429,"about_ca_topic_score_gemma":0.0007023414,"domain_scores_codex":[0.9998233,0.00001482181,0.00001280926,0.00006115305,0.00005156218,0.00003647488],"domain_scores_gemma":[0.9999133,0.000006041224,0.00003447543,0.000009181404,0.00001730428,0.00001971663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008250852,0.00001771812,0.0006903013,0.0001192837,0.00001272662,0.00008922677,0.00001397634,0.00009165057,0.9922255,0.0003486251,0.0003137355,0.005994566],"study_design_scores_gemma":[0.00002828824,0.0002490855,0.02883306,0.00003367812,0.00004387372,0.001562211,0.00004181839,0.002035742,0.9434029,0.0003533109,0.02340488,0.00001111472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360766,0.03304498,0.01524058,0.0009546886,0.0002119952,0.00008368351,0.002213262,0.0004451628,0.01172901],"genre_scores_gemma":[0.9763149,0.008339613,0.00301873,0.0001888892,0.00004498701,0.00004724572,0.00162277,0.00003761674,0.01038518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002479283,"threshold_uncertainty_score":0.008294046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092305893727813,"score_gpt":0.2478386061751241,"score_spread":0.236915547237846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}