{"id":"W1967703625","doi":"10.1371/journal.pone.0111956","title":"How Can We Get Close to Zero? The Potential Contribution of Biomedical Prevention and the Investment Framework towards an Effective Response to HIV","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"Medical Research Council; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; Imperial College London; World Health Organization; London School of Hygiene and Tropical Medicine; International AIDS Vaccine Initiative; University of Washington; Georgetown University; Bill and Melinda Gates Foundation; United States Agency for International Development","keywords":"Medicine; Psychological intervention; Intensive care medicine; Human immunodeficiency virus (HIV); Pre-exposure prophylaxis; Antiretroviral therapy; HIV vaccine; Viral load; Immunology; Vaccine trial; Men who have sex with men","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005084558,0.0009240082,0.0007265287,0.0009391973,0.002048025,0.007859673,0.001549126,0.004662829,0.01502849],"category_scores_gemma":[0.0150163,0.0003592911,0.0009414612,0.0007721522,0.006573439,0.01011095,0.003751233,0.005313962,0.001198333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00545345,"about_ca_system_score_gemma":0.00570014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008491756,"about_ca_topic_score_gemma":0.00607072,"domain_scores_codex":[0.9952756,0.00301184,0.00005423049,0.0003925568,0.0003985607,0.0008671965],"domain_scores_gemma":[0.9955465,0.002394579,0.0004185443,0.0002238249,0.0005865783,0.0008299705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00008642586,0.00009408443,0.001402694,0.0002985652,0.00006841225,0.0001670478,0.0004348491,0.01705177,0.0002022767,0.9384304,0.01922547,0.02253804],"study_design_scores_gemma":[0.00003332819,0.00007764778,0.0007798526,0.0004788435,0.00003451242,0.00006130851,0.0007541964,0.009220613,0.0001914015,0.9377928,0.05053769,0.00003779436],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.05717632,0.03033687,0.08180005,0.5678059,0.003512803,0.0002960423,0.0009054783,0.0002491538,0.2579173],"genre_scores_gemma":[0.9253365,0.01340448,0.01718164,0.026567,0.000840924,0.0003627879,0.0001797448,0.0001053804,0.0160217],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01502849,"threshold_uncertainty_score":0.05027527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01668103363677522,"score_gpt":0.3023338486723821,"score_spread":0.2856528150356069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}