{"id":"W1967703969","doi":"10.1021/jm050683z","title":"Design, Synthesis, and Molecular Modeling of a Novel Amide-Linked Cyclic GnRH Analogue Cyclo(4−9)[Lys<sup>4</sup>,<scp>d</scp>-Trp<sup>6</sup>,Glu<sup>9</sup>]GnRH:  Stimulation of Gonadotropin Gene Expression","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Amide; Cyclic peptide; Stereochemistry; Chemical synthesis; Peptide; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001113886,0.0002791194,0.0002991457,0.0000690819,0.0001736963,0.0003497049,0.0003445934,0.0003096956,0.001785131],"category_scores_gemma":[0.0001248843,0.0001660119,0.0002385993,0.00009104109,0.0001489097,0.0002030735,0.0001136273,0.0003209154,0.0003052581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004042013,"about_ca_system_score_gemma":0.0007021584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001731695,"about_ca_topic_score_gemma":0.001809905,"domain_scores_codex":[0.9999703,0.000004279655,0.000001270485,0.000006625665,0.00001083492,0.000006564675],"domain_scores_gemma":[0.9999683,0.000008319374,0.00000883317,0.000002408709,0.000005671557,0.000006472755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004057966,0.0002282171,0.001387313,0.0004268693,0.00006675876,0.0004883532,0.0001171122,0.7012879,0.269141,0.007445177,0.0007969255,0.01820846],"study_design_scores_gemma":[0.0001977315,0.0007007751,0.0006435799,0.00001658931,0.00005972537,0.0001433393,0.00007637797,0.90949,0.07956398,0.0008730573,0.008211499,0.00002346108],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.918541,0.001106679,0.06348694,0.0003961965,0.00006482939,0.0002280918,0.000655546,0.000376307,0.01514435],"genre_scores_gemma":[0.933966,0.001026429,0.06113097,0.00005917147,0.000009323688,0.0001554424,0.0006782771,0.00007850183,0.002895861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001785131,"threshold_uncertainty_score":0.005971849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502612606457304,"score_gpt":0.2450121511051832,"score_spread":0.2299860250406101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}