{"id":"W1967756629","doi":"10.1002/jnr.21352","title":"Enhanced accumulation of phosphorylated α‐synuclein in double transgenic mice expressing mutant β‐amyloid precursor protein and presenilin‐1","year":2007,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Presenilin; Amyloid precursor protein; Genetically modified mouse; Mutant; Phosphorylation; Neurite; Chemistry; Molecular biology; Transgene; Synuclein; Alzheimer's disease; Alpha-synuclein; Biology; Internal medicine; Biochemistry; Medicine; Parkinson's disease; In vitro; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001865088,0.0008526402,0.0004058662,0.0009034399,0.0002654023,0.000460746,0.0002228959,0.000554795,0.001623884],"category_scores_gemma":[0.0001711315,0.0005461122,0.0004073354,0.0002125267,0.0003069692,0.0003860231,0.0003323044,0.0007998099,0.0004260568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002598679,"about_ca_system_score_gemma":0.0001655494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005963555,"about_ca_topic_score_gemma":0.0008569264,"domain_scores_codex":[0.9997625,0.00002457572,0.00002710397,0.00007380268,0.00006236545,0.00004981163],"domain_scores_gemma":[0.9996589,0.00002552902,0.0001232331,0.00002101647,0.00002433516,0.0001469713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000327257,0.00007258607,0.0008381727,0.00002592958,0.00001545355,0.000344932,0.00003503238,0.00002530874,0.9976258,0.00004728426,0.00003058374,0.0006115943],"study_design_scores_gemma":[0.0002345223,0.003062748,0.1157877,0.00005231617,0.0001860857,0.0110753,0.0001792373,0.001621237,0.8636559,0.0003460469,0.003759519,0.00003943014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971433,0.0007249253,0.0009912028,0.00004149028,0.0000174495,0.00002584074,0.000325576,0.0001087373,0.000621383],"genre_scores_gemma":[0.9892797,0.001166875,0.003018036,0.0001003715,0.00003146466,0.00009106155,0.0009818608,0.0001007424,0.005229923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623884,"threshold_uncertainty_score":0.005432487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1644857146887604,"score_gpt":0.4517516392942023,"score_spread":0.2872659246054419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}