{"id":"W1967783066","doi":"10.1186/bcr3183","title":"Crk adaptor proteins act as key signaling integrators for breast tumorigenesis","year":2012,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal; Institute for Research in Immunology and Cancer; Centre Hospitalier de l’Université de Montréal; Université de Montréal; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Terry Fox Foundation; Natural Sciences and Engineering Research Council of Canada; McGill University; U.S. Department of Defense","keywords":"Adapter molecule crk; Signal transducing adaptor protein; Surgical oncology; Carcinogenesis; Breast cancer; Key (lock); Cancer research; Medicine; Computational biology; Signal transduction; Bioinformatics; Biology; Oncology; Internal medicine; Computer science; Cell biology; Cancer; Computer security","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001279414,0.0002220404,0.0001946553,0.0001534459,0.0003607451,0.00007638641,0.0003064424,0.0001852426,0.000339803],"category_scores_gemma":[0.0001146219,0.0001972497,0.0001614996,0.000319592,0.0001423261,0.00002083394,0.000145042,0.0002149524,0.00003628871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013239,"about_ca_system_score_gemma":0.0005840278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005392942,"about_ca_topic_score_gemma":0.0000519086,"domain_scores_codex":[0.9976803,0.000204302,0.000252434,0.0004456147,0.0005156517,0.0009017087],"domain_scores_gemma":[0.9985398,0.00003491849,0.00007810715,0.000381241,0.0005816601,0.0003842433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008407361,0.000140984,0.003645852,0.00009453892,0.00008139988,0.000002006619,0.0000885629,0.00003696057,0.9623126,0.0006563824,0.001175501,0.0309245],"study_design_scores_gemma":[0.0008853357,0.0001720596,0.008846228,0.000161111,0.00002038478,0.000147801,0.0002545451,0.0001023483,0.9506328,0.0001485687,0.03822019,0.0004086668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908443,0.002379653,0.002622285,0.001169616,0.0002237635,0.001574528,0.0006598207,0.00004350102,0.0004825002],"genre_scores_gemma":[0.994821,0.00006569312,0.0008410061,0.0001089265,0.002138337,0.00105616,0.00008932946,0.00006683441,0.0008126952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03704469,"threshold_uncertainty_score":0.8043608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04127538338156988,"score_gpt":0.3601581228991275,"score_spread":0.3188827395175576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}