{"id":"W1967809393","doi":"10.4161/auto.5269","title":"Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila","year":2008,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":709,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Autophagy; Biology; Neurodegeneration; Cell biology; Oxidative stress; Senescence; Longevity; Ageing; Gene expression; Ubiquitin; Gene; Genetics; Biochemistry; Internal medicine; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008430361,0.0002205687,0.0001797775,0.0002791582,0.0001225927,0.0002425881,0.0001479641,0.0001817954,0.0006163166],"category_scores_gemma":[0.00007699772,0.00013793,0.0001615945,0.00008087404,0.000170043,0.0001720529,0.0001670359,0.0003236635,0.0001696029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003677466,"about_ca_system_score_gemma":0.0001394953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007145923,"about_ca_topic_score_gemma":0.001535872,"domain_scores_codex":[0.9999315,0.000009730586,0.00001112785,0.00001647149,0.00001781482,0.00001350125],"domain_scores_gemma":[0.999886,0.00001555936,0.00003814504,0.00001246354,0.00001231605,0.00003549604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005305134,0.00001468213,0.0002082284,0.00002428768,0.000003160967,0.00002633046,0.0000115722,0.00004230695,0.9987709,0.00005912528,0.00002422573,0.0007619246],"study_design_scores_gemma":[0.00003118294,0.0004604424,0.01826423,0.00001651744,0.00003304581,0.0002484385,0.00004789898,0.001231654,0.9762033,0.0001397984,0.003313707,0.000009730387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972885,0.0008493927,0.0006217094,0.00004384949,0.000007848357,0.0000100236,0.0002436667,0.00003975634,0.0008953614],"genre_scores_gemma":[0.9948837,0.0008148745,0.001681128,0.00004431557,0.000005882475,0.00002531231,0.0003979183,0.00002391271,0.002122848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007145923,"threshold_uncertainty_score":0.002668202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01963883509253451,"score_gpt":0.2646342240566275,"score_spread":0.244995388964093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}