{"id":"W1967811803","doi":"10.1016/j.bmc.2006.03.054","title":"Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: Dual inhibitors of cyclooxygenases and lipoxygenases","year":2006,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Pharmacophore; Substituent; Stereochemistry; Structural isomer; Alkyl; Stereoselectivity; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002949102,0.0002980491,0.0002405229,0.0003244588,0.0001610395,0.0001830799,0.0002637677,0.0002781633,0.001163158],"category_scores_gemma":[0.0001563099,0.000142157,0.0002352379,0.0002360217,0.0001558902,0.0001783328,0.0001605973,0.0002314083,0.0002618945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002015971,"about_ca_system_score_gemma":0.0002344405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000561134,"about_ca_topic_score_gemma":0.0008952722,"domain_scores_codex":[0.9999154,0.00001574198,0.00001155086,0.00001345708,0.00001480173,0.00002910316],"domain_scores_gemma":[0.9999225,0.00001147926,0.00001940025,0.000007586371,0.00001291197,0.00002614241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007550405,0.0001993337,0.0001647644,0.00008932041,0.00001572804,0.0001745574,0.00003312384,0.0005761107,0.9910025,0.0002655177,0.00009205445,0.006632059],"study_design_scores_gemma":[0.0001615262,0.003431427,0.001037941,0.000007624862,0.00006480489,0.0002760197,0.00001917707,0.000483634,0.9910939,0.00005919349,0.00335382,0.00001087862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894738,0.003147065,0.003934756,0.0000826301,0.00003227471,0.0001390747,0.0005152531,0.00007950158,0.002595532],"genre_scores_gemma":[0.9924895,0.002256937,0.002807961,0.00004864077,0.0000141553,0.00004750762,0.0006031198,0.00001216039,0.001720103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163158,"threshold_uncertainty_score":0.00389117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157521089693258,"score_gpt":0.2752556636309042,"score_spread":0.2536804527339716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}