{"id":"W1967823782","doi":"10.1152/ajpheart.00088.2011","title":"Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Sex and Gender in Healthcare","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Heart Institute; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; DNA methylation; Estrogen receptor; Biology; Androgen receptor; Hormone; Estrogen; Methylation; Epigenetics; CpG site; Estrogen receptor alpha; Methyltransferase; Gene expression; DNA; Medicine; Gene; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680106,0.0002085277,0.001067922,0.0004107599,0.00008201047,0.00000263309,0.00006814694,0.0001368565,0.00001889855],"category_scores_gemma":[0.00004661684,0.0001624136,0.0001792956,0.0003003639,0.0004508429,0.00009728629,0.00002509354,0.0003267711,2.822324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002893239,"about_ca_system_score_gemma":0.00009185595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065106,"about_ca_topic_score_gemma":0.000002007773,"domain_scores_codex":[0.9982005,0.000456066,0.0005902505,0.0003525644,0.0001606495,0.0002399622],"domain_scores_gemma":[0.9986516,0.000129245,0.0005157175,0.0002329412,0.0003090622,0.000161466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006456763,0.00007297946,0.008255271,0.00007311838,0.0003200289,0.000003297494,0.0007466655,0.00008573116,0.9894739,0.00004866737,0.000005602578,0.0002690398],"study_design_scores_gemma":[0.001616506,0.001710542,0.9527748,0.00007357906,0.0003474237,0.0002557773,0.002007114,0.0003764775,0.03613996,0.004532281,0.00001559373,0.0001499208],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958416,0.003641601,0.0001640211,0.00001839254,0.000152093,0.000163407,0.000005778,0.000007673497,0.000005412022],"genre_scores_gemma":[0.9985979,0.0001952995,0.0006151678,0.0003861052,0.0001814449,0.000001808039,0.00000619639,0.00001572644,4.011092e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.953334,"threshold_uncertainty_score":0.6623033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03227727930889928,"score_gpt":0.2898694761622845,"score_spread":0.2575921968533852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}