{"id":"W1967861180","doi":"10.1016/j.neurobiolaging.2012.11.006","title":"Segmental duplications in genome-wide significant loci and housekeeping genes; warning for GAPDH and ACTB","year":2012,"lang":"en","type":"article","venue":"Neurobiology of Aging","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Occupational Cancer Research Centre","funders":"National Human Genome Research Institute; W. Garfield Weston Foundation; Canadian Institutes of Health Research; University of California, Santa Cruz","keywords":"Housekeeping gene; Biology; Genetics; Single-nucleotide polymorphism; Genome-wide association study; Genome; Gene; Computational biology; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001925557,0.0001086347,0.0001405656,0.00005482439,0.00007952385,0.000004611694,0.00008501729,0.000120645,0.000001963503],"category_scores_gemma":[0.00002873541,0.0001118237,0.00003374149,0.00004296571,0.0001493502,0.000003567184,0.0001166191,0.00007445017,3.385845e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006219197,"about_ca_system_score_gemma":0.00001250613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001406839,"about_ca_topic_score_gemma":0.000006547622,"domain_scores_codex":[0.9992288,0.00004786747,0.0001846657,0.0002744546,0.00001746289,0.0002467652],"domain_scores_gemma":[0.9996198,0.00004480102,0.00009055612,0.0001703899,0.00002178659,0.00005266548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000841913,0.00002894561,0.1418605,0.00001775373,0.00001332593,1.231374e-7,0.00004321552,0.000008881773,0.856804,0.000184136,0.00004593659,0.0009847576],"study_design_scores_gemma":[0.0006104092,0.0002446753,0.3261646,0.0000153518,0.00003575491,0.00003826043,0.0001098465,0.00006494324,0.6559069,0.0001145647,0.01639822,0.0002964811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901243,0.001104268,0.007962783,0.0003632088,0.00001975376,0.0003248444,0.00001963122,0.00001414944,0.00006708068],"genre_scores_gemma":[0.9938886,0.0005544327,0.004815288,0.0004108483,0.00004990207,0.00010838,0.0001324601,0.000016491,0.00002359981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2008971,"threshold_uncertainty_score":0.4560038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115791319572984,"score_gpt":0.2595200287619828,"score_spread":0.2479408968046844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}