{"id":"W1967864075","doi":"10.1016/j.febslet.2007.05.033","title":"Caspase‐3‐mediated cleavage of Akt: Involvement of non‐consensus sites and influence of phosphorylation","year":2007,"lang":"en","type":"article","venue":"FEBS Letters","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Phosphorylation; Cleavage (geology); AKT1; Cell biology; Protein kinase B; Caspase; Chemistry; Kinase; Apoptosis; Biology; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002498635,0.00009790101,0.0001490265,0.00005408268,0.00001523894,0.000002488156,0.00008838233,0.00008406472,0.000004054892],"category_scores_gemma":[0.00008417497,0.000100928,0.00004126331,0.00009325551,0.0001871868,0.00000270327,0.00004736424,0.00004972405,6.745811e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001412442,"about_ca_system_score_gemma":0.00002877215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001623812,"about_ca_topic_score_gemma":0.00005237768,"domain_scores_codex":[0.9992171,0.00001962726,0.0003058369,0.0001774777,0.0001383753,0.0001416014],"domain_scores_gemma":[0.9993767,0.00004569319,0.0002360414,0.0002070833,0.00009465848,0.00003986331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001265463,0.00002441652,0.05056791,0.00007719563,0.00004452419,0.000003102304,0.000132427,0.0004044322,0.9474186,0.000003659598,0.000941742,0.0002554686],"study_design_scores_gemma":[0.0004328734,0.0001750958,0.07155393,0.00004016909,0.00001838322,0.000001656678,0.00004647259,0.00003042453,0.927362,0.000004260481,0.0002463564,0.00008834193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988222,0.0004230833,0.0003595421,0.0001197042,0.00004586532,0.0001233565,0.00003558292,0.000003629722,0.00006704526],"genre_scores_gemma":[0.9985762,0.00002934174,0.0007483548,0.0005405337,0.00003766255,0.000002658734,0.00004465146,0.00001101938,0.000009560807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02098603,"threshold_uncertainty_score":0.4115725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008641059851664001,"score_gpt":0.2422770630553311,"score_spread":0.2336360032036671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}