{"id":"W1967866035","doi":"10.1007/s00280-002-0538-z","title":"The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925","year":2002,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Dexrazoxane; Chemistry; Doxorubicin; Pharmacology; Calcein; Pharmacokinetics; Chelation; In vivo; Medicine; Biochemistry; Internal medicine; Chemotherapy; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002034151,0.0004126138,0.0003133786,0.0003549289,0.0002357736,0.000320488,0.0002426246,0.0003606206,0.001907688],"category_scores_gemma":[0.0002073037,0.0003286106,0.0002661095,0.0001874799,0.0003509503,0.0004028929,0.0001105369,0.0004828375,0.0004711782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003971144,"about_ca_system_score_gemma":0.0004487445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002013281,"about_ca_topic_score_gemma":0.002144403,"domain_scores_codex":[0.9998716,0.00002981996,0.000008010356,0.00003907078,0.000017421,0.00003412334],"domain_scores_gemma":[0.9998461,0.00001729009,0.00006788038,0.00002414625,0.00001365478,0.00003075303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005331041,0.00009702086,0.001159754,0.0000671999,0.00002850045,0.0001105493,0.00005561109,0.0002282768,0.9850119,0.0003127511,0.00009690961,0.007500388],"study_design_scores_gemma":[0.0001131662,0.002829149,0.007898016,0.00001006829,0.0000614733,0.0003863385,0.00005791472,0.0008995943,0.9856477,0.0001060278,0.001975539,0.00001513134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933767,0.002488553,0.002702503,0.0001223285,0.00003008064,0.00002118901,0.0002593391,0.00008307715,0.0009163487],"genre_scores_gemma":[0.993601,0.001427826,0.001322414,0.00004038441,0.00001179045,0.00001393355,0.0003991965,0.00002598405,0.003157333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002013281,"threshold_uncertainty_score":0.00638181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242555805675167,"score_gpt":0.3075348498684479,"score_spread":0.2832792693009312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}