{"id":"W1967870961","doi":"10.1021/nn1021007","title":"Interactions of Poly(amidoamine) Dendrimers with Human Serum Albumin: Binding Constants and Mechanisms","year":2011,"lang":"en","type":"article","venue":"ACS Nano","topic":"Dendrimers and Hyperbranched Polymers","field":"Materials Science","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"California Institute of Technology","keywords":"Poly(amidoamine); Dendrimer; Amidoamine; Human serum albumin; Biophysics; Chemistry; Serum albumin; Plasma protein binding; Binding constant; Materials science; Binding site; Polymer chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958724,0.0003529655,0.0002621958,0.0001546883,0.0002140126,0.0002295052,0.0003481657,0.0004496301,0.0005018804],"category_scores_gemma":[0.0004534992,0.0001725785,0.0002120127,0.00009789345,0.0002857366,0.0003563958,0.0002590197,0.0002754036,0.0002247328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007578491,"about_ca_system_score_gemma":0.0001962532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002208376,"about_ca_topic_score_gemma":0.001485318,"domain_scores_codex":[0.9998659,0.00002172316,0.000006089537,0.00003524826,0.00004604098,0.00002503328],"domain_scores_gemma":[0.9998239,0.00008458077,0.00004152182,0.000008929697,0.00002261131,0.0000185565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008270385,0.0000210571,0.001219999,0.0000675922,0.00001535738,0.00005253229,0.00004308382,0.002999555,0.9925525,0.0003160883,0.0000525387,0.002576929],"study_design_scores_gemma":[0.00001007442,0.0001587051,0.006188338,0.000004500362,0.00001481807,0.0001294965,0.00003576227,0.02906953,0.9632437,0.0002615427,0.000864163,0.00001925721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920877,0.00087943,0.006250803,0.00007626239,0.000006756767,0.0000170216,0.00004516717,0.0000529663,0.0005838311],"genre_scores_gemma":[0.9965398,0.0003828771,0.002247071,0.00003846369,0.000003462811,0.00002316585,0.00004875764,0.000007539344,0.0007088149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002208376,"threshold_uncertainty_score":0.005498588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02840137065534587,"score_gpt":0.2460910405784977,"score_spread":0.2176896699231518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}