{"id":"W1967882148","doi":"10.1042/0264-6021:3610653","title":"Cell-permeable ceramides preferentially inhibit coated vesicle formation and exocytosis in Chinese hamster ovary compared with Madin‒Darby canine kidney cells by preventing the membrane association of ADP-ribosylation factor","year":2002,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Fondation pour la Recherche Médicale; Canadian Diabetes Association; Heart and Stroke Foundation of Canada","keywords":"Chinese hamster ovary cell; Phospholipase D; Golgi apparatus; Cell biology; Ceramide; ADP ribosylation factor; Biology; Exocytosis; Cytosol; Molecular biology; Biochemistry; Membrane; Endoplasmic reticulum; Signal transduction; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002476136,0.0007656713,0.0007985472,0.0002963948,0.0002711722,0.0004904919,0.0004266764,0.0003152259,0.001329036],"category_scores_gemma":[0.0002056322,0.0002611848,0.0004829788,0.0003686399,0.0003024545,0.0003043248,0.0002944006,0.0005695139,0.0004301733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005990832,"about_ca_system_score_gemma":0.0004118175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001237514,"about_ca_topic_score_gemma":0.001832673,"domain_scores_codex":[0.9996594,0.00005865406,0.0000579111,0.0000554502,0.00008630373,0.00008223332],"domain_scores_gemma":[0.9998411,0.00004014873,0.00003365582,0.00002420898,0.00002236246,0.00003851588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002555342,0.00003238409,0.00009874041,0.00005560402,0.00001297751,0.00004506087,0.00001970622,0.00003243645,0.9987416,0.00007869869,0.0000356486,0.0005917358],"study_design_scores_gemma":[0.00002904806,0.0002910777,0.00132572,0.000002447817,0.00002049806,0.0001097679,0.00001036746,0.0003393021,0.9967847,0.00001622834,0.001067078,0.000003833084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915233,0.004405347,0.001243238,0.0001063599,0.00008105883,0.00006567307,0.0005353814,0.0001054549,0.001934215],"genre_scores_gemma":[0.9894753,0.003243623,0.002522778,0.00008508733,0.00004148166,0.0001176621,0.001673598,0.000035546,0.002804973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329036,"threshold_uncertainty_score":0.004446089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007706038699171298,"score_gpt":0.197541185267329,"score_spread":0.1898351465681577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}