{"id":"W1967887313","doi":"10.1038/nsmb.1432","title":"Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states","year":2008,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cancer Research Society; Leukemia and Lymphoma Society","keywords":"Histone methylation; Histone methyltransferase; Histone code; EZH2; Histone H3; Biology; Methylation; Epigenomics; Histone H1; Computational biology; Histone; DNA methylation; Genetics; Gene expression; Gene; Nucleosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001724417,0.0002892446,0.0003116798,0.0001441219,0.0001483986,0.000008505411,0.000207209,0.0007096316,0.00004514812],"category_scores_gemma":[0.0002866578,0.0002651155,0.0001481465,0.000301234,0.0001842005,0.000009938306,0.00009531952,0.0003074766,0.000003990334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004477711,"about_ca_system_score_gemma":0.0001017361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004018818,"about_ca_topic_score_gemma":0.00001332942,"domain_scores_codex":[0.9982197,0.0001750919,0.0004349799,0.0006187249,0.0002362126,0.0003152983],"domain_scores_gemma":[0.998735,0.00002737777,0.0002745995,0.0003477923,0.0004927553,0.0001224935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001736657,0.00001558337,0.002013797,0.00001487571,0.00006319767,0.000002090849,0.00006902147,0.0008596125,0.9929749,0.0005579714,0.0006260871,0.002629228],"study_design_scores_gemma":[0.0005052086,0.0005099932,0.008670155,0.000006280149,0.00002930976,0.00001263864,0.00001303991,0.00008224146,0.9803625,0.002675474,0.006837275,0.0002958948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.944027,0.01143942,0.04300952,0.0003962481,0.0004368008,0.0003011512,0.0001223305,0.00001889644,0.000248649],"genre_scores_gemma":[0.9918876,0.0002068965,0.004272506,0.0003939109,0.0001722059,0.00002221553,0.002755684,0.00003390055,0.0002550538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04786064,"threshold_uncertainty_score":0.9999801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006379815347929852,"score_gpt":0.3156155320533264,"score_spread":0.3092357167053965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}