{"id":"W1967887313","doi":"10.1038/nsmb.1432","title":"Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states","year":2008,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Cancer Research Society; Leukemia and Lymphoma Society","keywords":"Histone methylation; Histone methyltransferase; Histone code; EZH2; Histone H3; Biology; Methylation; Epigenomics; Histone H1; Computational biology; Histone; DNA methylation; Genetics; Gene expression; Gene; Nucleosome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003323802,0.0004165497,0.000506139,0.0002242172,0.000299012,0.0007231481,0.0007522058,0.0005459608,0.002281396],"category_scores_gemma":[0.0004302908,0.000490858,0.000349069,0.0001780225,0.0004507994,0.0004521111,0.001058641,0.0009886905,0.001162382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006718494,"about_ca_system_score_gemma":0.0002877317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006162648,"about_ca_topic_score_gemma":0.001178695,"domain_scores_codex":[0.999657,0.0000255798,0.00003288317,0.0001150583,0.00008671323,0.00008273035],"domain_scores_gemma":[0.9994454,0.000093503,0.0001193663,0.0001662746,0.0000561357,0.0001193213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009819284,0.00001131104,0.0001969295,0.00001737881,0.000005210963,0.00005045533,0.00000941218,0.00004740622,0.9985624,0.0002412605,0.00003877683,0.0007212871],"study_design_scores_gemma":[0.00001168957,0.00003375761,0.002233969,0.000001490498,0.000007568408,0.0002011366,0.00001569746,0.0008995682,0.9958715,0.0001301251,0.0005874467,0.000006042266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929848,0.0006020071,0.004412728,0.0001221098,0.00005731038,0.00001306137,0.0002662052,0.0002341873,0.001307622],"genre_scores_gemma":[0.9971739,0.00009910634,0.0009322561,0.0000344568,0.000003994313,0.000009069397,0.0002803979,0.0000755738,0.001391144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002281396,"threshold_uncertainty_score":0.007632017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006379815347929852,"score_gpt":0.3156155320533264,"score_spread":0.3092357167053965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}